CAS: 58543-16-1; (2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-Yl (4R,4As,6Ar,9S,11Ar,11Bs)-9-(((2S,3R,4S,5R,6R)-5-Hydroxy-6-(Hydroxymethyl)-3,4-Bis(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-P

该化合物是来自Stevia rebaudiana 叶子的高纯度石墨糖. 它是一个非卡罗里,天然甜点,甜度大约是苏格罗塞的200-400倍. 与其他steviol glycosides不同的是, Rebaudioside A 表现出了最低的苦度和后继性,使之适合需要清洁甜度描述的应用. 它在高温和酸性条件下保持稳定,能够用于烘烤食品,饮料和加工食品. 作为零甘甜剂,它对于糖尿病和低热量配方是理想的. 它的高溶性及其与其他成分的兼容性进一步增强了其在食品和制药行业的实用性.

结构式图片

上下游产品

CAS号58543-17-2 莱苞迪甙B; 莱苞迪苷B | CAS号41093-60-1 甜菊双糖苷

合成工艺路线路线简述

    尿苷(5')二氢二磷酰(1)-Alpha-D-葡萄糖置于ugt76G1,Ugt91D2,Magnesium Chloride体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应 1.0H,反应生成 瑞鲍迪甙 A
    参考文献: High-Purity Steviol Glycosides[fr] Glycosides De Stéviol De Haute Pureté
    标题: High-Purity Steviol Glycosides[fr] Glycosides De Stéviol De Haute Pureté
    摘要:描述了制备高度纯化的蒸馏甘甜苷,特别是蒸甘甜苷a,D和m的方法.这些方法包括利用重组微生物将各种原始成分转化为目标蒸甘甜苷.此外,还披露了新型蒸甘甜苷reb D2,Reb M2和reb I,以及它们的制备方法.这些高度纯化的蒸甜苷可作为无热量甜味剂,用于食用和可咀嚼的产品,如任何饮料,糖果,烘焙产品,饼干和口香糖.

    专利信息


    专利号:US-10040752-B2
    优先权日:2015-08-24
    标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
    发明人:MKRTCHYAN GNEL; YAO QINGWEI
    权利人:CODY LABORATORIES INC
    摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

    专利号:US-7402418-B2
    优先权日:2001-09-20
    标 题:Genes participating in the synthesis of fatty acid having trans-11-,cis-13-conjugated double bond and utilization thereof
    发明人:OSUMI MARI; MURASE JUNKO; IMAMURA JUN
    权利人:PLANTECH RES INST; INC ADMIN AGENCY NARO
    摘要:An object of the present invention is to clone a gene which is involved in synthesis of fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bone at position Δ12. The present invention provides a gene having any one of the following nucleotide sequences:n (A) a nucleotide sequence encoding an amino acid sequence shown in SEQ ID NO: 1 or 12; (B) a nucleotide sequence encoding an amino acid sequence comprising a deletion, addition or substitution of one or several amino acids with respect to the amino acid sequence shown in SEQ NO: 1 or 12, and having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12; (C) a nucleotide sequence shown in SEQ ID NO: 2 or 13; (D) a nucleotide sequence comprising a deletion, addition or substitution of one or several nucleotides with respect to the nucleotide sequence shown in SEQ ID NO: 2 or 13, and encoding a protein having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12; and (E) a nucleotide sequence hybridizing with the nucleotide sequence shown in SEQ ID NO: 2 or 13 or a complementary sequence thereof under stringent conditions, and encoding a protein having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12.

    专利号:US-RE40849-E
    优先权日:1998-04-30
    标题:Method of treatment of glutathione deficient mammals
    发明人:KELLER ROBERT H; KIRCHENBAUM DAVID W
    权利人:VIT IMMUNE L C
    摘要:Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intracellulary either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels. The disclosure is also of a unique combination of nutritional supplements including n-acetyl cysteine, vitamin C, l-glucosamine, n-acetyl d-glucosamine, quercitin, sylimarin, Alpha lipoic acid and high protein, low fat whey that are combined to support various bodily systems involved in glutathione synthesis, reutilization and storage; all intended to elevate glutathione concentration in the mammalian cell.

    专利号:US-2017204442-A1
    优先权日:2014-05-29
    标题 :Enzymatic synthesis of soluble glucan fiber
    发明人:DICOSIMO ROBERT; CHENG QIONG; ELIOT ANDREW C; OUWEHAND ARTHUR; PAYNE MARK S; YOU ZHENG
    权利人:DU PONT
    摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.

    专利号:US-7811612-B2
    优先权日:2005-01-20
    标 题 :Herbal mixture extract of notoginseng radix, rehmanniae radix preparata and acanthopanacis cortex and composition comprising the same for prevention and treatment of arthritis
    发明人:KIM JUNG-KEUN; KIM SE-WON; KIM HYUNG-GUN; KO SEON-YLE; BAEK DONG-HEON; CHANG SUNHWA
    权利人:OSCOTEC INC
    摘要:The present invention relates to an extract of an herbal mixture of Notoginseng radix, Rehmanniae radix preparata and Acanthopanacis cortex , and a method for treating arthritis using the extract as an effective ingredient. The extract of the herbal mixture of the present invention can effectively inhibits the release of inflammatory substances and the synthesis of cartilage destroying substance as well as the progress of arthritis.

    专利号:US-10231914-B2
    优先权日:2015-06-02
    标题:Effervescent tablet for elimination of red wine discoloration, offensive odour of mouth and cleaning the palate
    发明人:BATTON LYNETTE
    权利人:BATTON LYNETTE
    摘要:The embodiments herein discloses a composition and method for the synthesis of an effervescence producing tablet for reducing and eliminating a mouth odor and oral staining caused by ingested beverages and food. The method comprises mixing excipients, disintegrating agents, flavor and sweetener in a V-blender. The lubricant is added V-blender to obtain a mixture. The mixture is compressed on tablet press equipment with a round tooling. The tablets are packaged in a foil pouch. The “excipients†in the effervescent tablet composition are malic acid, sorbitol, potassium bi-carbonate, microcrystalline cellulose, sodium chloride, sodium carbonate and magnesium oxide. The malic acid react with potassium bicarbonate or sodium bicarbonate or sodium carbonate to form an effervescence reaction to induce tablet disintegration, provide a pleasant sensation in the mouth, and to clean a wine stain in the mouth.
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    主要参考文献


    1: Wong RR, Chung SJ, Hong JH, Park S. Sweetness interaction between a novel glycosylated rebaudioside A and various sweeteners in a binary mixture system. Food Sci Biotechnol. 2024 Mar 27;33(13):2999-3007. doi: 10.1007/s10068-024-01552-w.
    2: Yang Y, Liu Y, Xu M, Cai J, Li Q, Wan Z, Yang X. Hierarchical Self- Aggregation of Multifunctional Steviol Glycosides in Aqueous Solutions. J Agric Food Chem. 2024 Jul 24;72(29):16438-16448. doi: 10.1021/acs.jafc.4c02386. Epub 2024 Jul 9. 100(7):1104-1115. doi: 10.1080/09553002.2024.2362647. Epub 2024 Jun 13.
    2024:6693085. doi: 10.1155/2024/6693085.

    合成参考文献


    摘要:
    摘要:Lipinski G-W; Ullmann's Encyclopedia of Industrial Chemistry. 7th ed. (2008). New York, NY: John Wiley & Sons; Sweeteners. Online Posting Date: 15 June 2000
    参考文献:10.1007/bf01965774
    摘要:Wingard RE, Brown JP, Enderlin FE, Dale JA, Hale RL, Seitz CT. Intestinal degradation and absorption of the glycosidic sweeteners stevioside and rebaudioside A. Cellular and Molecular Life Sciences. 1980 May;36(5):519–20. doi: 10.1007/bf01965774.
    参考文献:10.1021/acs.jafc.9b02545
    摘要:Guo Q, Zhang T, Wang N, Xia Y, Zhou Z, Wang JR, Mei X. RQ3, A Natural Rebaudioside D Isomer, Was Obtained from Glucosylation of Rebaudioside A Catalyzed by the CGTase Toruzyme 3.0 L. J Agric Food Chem. 2019 Jul 17;67(28):8020–8. doi: 10.1021/acs.jafc.9b02545.
    参考文献:10.1007/bf03191014
    摘要:Rašković A, Mikov M, Škrbić R, Jakovljević V, Vasović V, Posa M, Kuhajda K, Kevrešan S, Tomic Z, Siladji D. Effect of stevioside and sodium salt of monoketocholic acid on glycemia in normoglycemic and diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics. 2008 Mar;33(1):17–22. doi: 10.1007/bf03191014.
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