CAS: 5551-11-1; 4-Chloro-2-Nitrobenzaldehyde

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📜甲二醇,(4-氯-2-硝基苯基)-,二乙酸酯(Ester)置于盐酸体系中,化学反应生成 4-氯-2-硝基苯甲醛
参考文献:杂环碱性化合物;3,6-二氯-9-(1-甲基-4-二乙基氨基丁)-氨基ac啶.
标题:杂环碱性化合物;3,6-二氯-9-(1-甲基-4-二乙基氨基丁)-氨基ac啶.
摘要:
DOI:10.1021/ja01212A068

专利信息

专利号:US-2009048451-A1
优先权日:2007-08-16
标题 :Synthesis of triazole derivatives from Lewis base mediated nitroalkene-aldehyde coupling
发明人：SHI XIAODONG
权利人:UNIV WEST VIRGINIA
摘要:In the present invention a method to synthesize a triazole derivative from a Lewis base mediated nitroalkene-aldehyde coupling is revealed. In this synthesis a nitroalkene is reacted with an aromatic aldehyde in the presence of a Lewis Base, NaN 3 , and a solvent for about 2 hours to about 48 hours at ambient conditions such as room temperature. The synthesized product may be any type of 4,5 disubstituted-1,2,3-triazoles. Of the nitroalkenes alkenes most β-alkyl nitroalkenes can react such as a β-substituted alkene. The aromatic aldehyde can be any 6 carbon aromatic aldehyde whether unsubstituted, substituted, disubstituted, heterocyclic, or a five carbon thiophene carboxaldehyde. The reaction takes place in the presence of NaN 3 , a Lewis base, and solvents.

专利号:US-9085605-B2
优先权日:2010-05-27
标 题:Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
发明人：LIU GANG; ZHAO NAN; MA YAO
权利人:LIU GANG; ZHAO NAN; MA YAO; SHENZHEN SALUBRIS PHARM CO LTD
摘要:The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as shown by formula I. Specifically, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.

专利号:EP-3239139-B1
优先权日:2010-05-27
标题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

专利号:US-2013143826-A1
优先权日:2010-05-27
标 题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

专利号:EP-2612857-B1
优先权日:2010-05-27
标 题:Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

专利号:EP-3239139-A1
优先权日:2010-05-27
标题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate