CAS: 53363-89-6; Boc-N-Me-Leu-Oh

相似化合物

89536-84-5 103478-62-2 103478-63-3

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CAS号13139-15-6 B°C-L-亮氨酸 | CAS号74-88-4 碘甲烷 | CAS号77-78-1 硫酸二甲酯 | CAS号61-90-5 L-亮氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈

L-亮氨酸 在 Sodium Hydride,Sodium Hydroxide体系中,用 四氢呋喃,水,Mineral Oil作为反应溶剂,反应 24.25H,获得 N-T-Butoxycarbonyl-N-Methyl-L-Leucine
参考文献:D-氨基酸位置影响galaxamide类似物的抗癌活性:细胞凋亡机制研究.
标题:D-氨基酸位置影响galaxamide类似物的抗癌活性:细胞凋亡机制研究.
摘要:Galaxamide是一种来自galaxaurafilosa的提取物,是一种含有五种l-亮氨酸的环状五肽.由于特殊的环状结构和优异的抗癌活性,Galaxamide及其类似物的合成及其后续的生物应用引起了极大的关注.在目前的工作中,我们通过用苯丙氨酸代替一个亮氨酸取代了一个l-亮氨酸,并改变了d-氨基酸的位置,从而合成了六个galaxamide类似物.测试了合成的galaxamide类似物对四种体外人类癌细胞系,人类肝细胞细胞(Hepg2),人类乳腺癌细胞(Mcf-7),人类乳腺癌细胞(Mda-Mb-435)的抗癌作用.宫颈癌细胞系(Hela).结果表明,具有不同d-氨基酸位置的galaxamide类似物显示出独特的抗癌潜力.在位置5(Analog-6)上含有d-氨基酸的galaxamide类似物具有最强的抗癌活性.机制研究表明,Analog-6可能通过抑制hepg2细胞在细胞周期亚g1期的
Doi:10.3390/Ijms18030544

专利信息

专利号:US-12122759-B2
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides
发明人：HEIMBACH DIRK; OMURA SATOSHI; SUNAZUKA TOSHIAKI; HIROSE TOMOYASU; NOGUCHI YOSHIHIKO; Köbberling Johannes; WU ZHIJIE; FU SHUIBIAO; WU WEI; QIU JINFENG; HE LIU; WEI XUDONG
权利人:ELANCO ANIMAL HEALTH GMBH; THE KITASATO INST
摘要:The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.

专利号:US-4396542-A
优先权日:1980-02-14
标 题 :Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
发明人：WENGER ROLAND
权利人:SANDOZ LTD
摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

专利号:US-4554351-A
优先权日:1980-02-14
标 题:Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
发明人：WENGER ROLAND
权利人:SANDOZ LTD
摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2025019360-A1
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides

专利号:EP-3676265-A1
优先权日:2017-11-07
标 题 :Method for the synthesis of cyclic depsipeptides