专利号:US-4895954-A 优先权日:1986-07-26 标题 :Precursors for synthesis of triphendioxazine dyestuffs 发明人:SCHWAIGER GUENTHER; SPRINGER HARTMUT; HELMLING WALTER 权利人:HOECHST AG 摘要:Water-soluble triphendioxazine compounds which have fiber-reactive properties as dyestuffs, which afford deep and fast dyeings on fiber materials, such as wool and, in particular, cellulose, and which correspond to the formula (1) ##STR1## in which: n is the number 0 or 1; n Y is the vinyl group or an ethyl group containing, in β-position, a substituent which can be eliminated by means of an alkali; n Q 1 and Q 2 both represent a benzotriazole radical which can also be additionally substituted in the benzene nucleus by alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen, carboxy or sulfo; n B is --O--, --S--, --NH-- or --N(R')-- wherein R' is optionally substituted alkyl having 1 to 6 carbon atoms; n W 1 and W 2 both represent a divalent, optionally substituted aliphatic, cycloaliphatic, aliphatic-cycloaliphatic, araliphatic or aromatic-carbocyclic radical, it being possible for the aliphatic radicals to be interrupted by hetero groups --O--, --S--, --SO 2 --, --CO--, 1,4-piperidino, --NH-- and/or --N(R o )-- in which R o is optionally substituted alkyl having 1 to 6 carbon atoms or alkanoyl having 2 to 5 carbon atoms, and/or for aliphatic and aryl radicals to be attached to one another through such a hetero group; n R is hydrogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, halogen, carboxyl or sulfo; n E is hydrogen, sulfo, carboxyl, a group --SO 2 --Y as defined above or an optionally substituted sulfonamide group; and n X 1 and X 2 are both hydrogen or halogen, cycloalkyl, alkoxy, aryloxy, aryl or another substituent; n and at least one carboxy, sulfo or sulfato group is present in the molecule (1), n and pre-products of those triphendioxazine compounds, of the general formula ##STR2## in which K is an amino or nitro group, Y' is β-hydroxyethyl or defined as for Y, W has one of the meanings of W 1 , and E' is hydrogen, sulfo, carboxy or a group of the formula --SO 2 --Y' defined above, or an optionally substituted sulfonamide group, and R, B and R* have the above meanings.
专利号:US-2025154548-A1 优先权日:2023-11-09 标 题:Control of enzymatic nucleic acid synthesis via electrochemical means 发明人:BRYAN CASSIE M; SPRACHMAN MELISSA; DOYLE ROBERT; RECORDS WILLIAM C 权利人:CHARLES STARK DRAPER LABORATORY INC 摘要:Provided herein are methods of nucleic acid synthesis. In some embodiments, a method of nucleic acid synthesis comprises selectively activating and deactivating an engineered terminal deoxynucleotidyl transferase (TdT). In some embodiments, a method of nucleic acid synthesis comprises activating a pH sensitive enzyme to digest and remove a TdT.
专利号:US-2022323924-A1 优先权日:2021-03-24 标题:Electrochemical polynucleotide synthesis 发明人:LACKEY JEREMY; HABIBIAN MARYAM; LIN YANYOU 权利人:TWIST BIOSCIENCE CORP 摘要:Provided herein are compositions, devices, systems and methods for generation and use of biomolecule-based information for storage. Further provided are devices comprising addressable electrodes controlling polynucleotide synthesis (deprotection, extension, or cleavage, etc.) Further provided are compositions for low voltage deprotection of polynucleotides.
专利号:US-7368624-B2 优先权日:2004-03-30 标 题 :Synthesis for polycyclic aromatic hydrocarbon compounds 发明人:BROWN CHRISTOPHER T; SHUKLA DEEPAK; DOCKERY KEVIN P; LENHARD JEROME R; MATZ JAMES R 权利人:EASTMAN KODAK CO 摘要:A process for forming an aryl-aryl bond comprises the step of reacting an arene hydrocarbon compound with either (1) an organic oxidant selected from the group consisting of a quinone, a quinone imine, a quinone diimine, and a nitroarene, or (2) an oxidizing salt selected from the group consisting of a triarylaminium salt, an oxonium salt, and a nitrosium salt, or (3) a hypervalent iodine compound, each in the presence of a Brönsted or Lewis acid.
专利号:US-3931325-A 优先权日:1974-03-04 标题 :Perfluorocyclohexene-1,4-dione 发明人:DOORENBOS HAROLD E; FRICK HUGHIE R 权利人:DOW CHEMICAL CO 摘要:Two new organic compounds are disclosed, perfluorocyclohexane-1,4-dione and perfluorocyclohexene-1,4-dione, which are obtained concurrently or alternatively by reacting fluoranil with substantially pure anhydrous cobalt trifluoride. These compounds are clear, colorless liquids which are useful as monomers in the synthesis of thermally stable elastomeric polymers. Also disclosed is the dihydrate of said perfluorocyclohexane-1,4-dione, namely, octafluoro-1,1,4,4-cyclohexanetetraol. Another aspect of this invention is a series of polyethers formed by reacting said perfluorocyclohexane-1,4-dione with cesium fluoride and a cyclic or noncyclic aliphatic perhaloalkene having from 2 to 12 carbon atoms and a fluorine atom on at least each of the carbon atoms connected by the double bond, said polymer having as a repeating unit WHEREIN R is a divalent radical selected from the group consisting of -C=C- and -C = C- ANGLE ¦¦ CnX2n X2y+1CyCzX2z+1 WHEREIN X is a halogen selected from the group consisting of fluorine, chlorine, bromine, iodine, or any stable combination thereof within the same molecule; N IS AN INTEGER OF FROM 1 TO 4; Y IS AN INTEGER OF FROM 0 TO 10; AND Z IS AN INTEGER OF FROM 0 TO (10-Y).
专利号:US-3996200-A 优先权日:1974-03-04 标 题 :Perfluorinated para-diketone polymers 发明人:DOORENBOS HAROLD E; FRICK HUGHIE R 权利人:DOW CHEMICAL CO 摘要:Two new organic compounds are disclosed, perfluorocyclohexane-1,4-dione and perfluorocyclohexene-1,4-dione, which are obtained concurrently or alternatively by reacting fluoranil with substantially pure anhydrous cobalt trifluoride. These compounds are clear, colorless liquids which are useful as monomers in the synthesis of thermally stable elastomeric polymers. Also disclosed is the dihydrate of said perfluorocyclohexane-1,4-dione, namely, octafluoro-1,1,4,4-cyclohexanetetraol. Another aspect of this invention is a series of polyethers formed by reacting said perfluorocyclohexane-1,4-dione with cesium fluoride and a cyclic or noncyclic aliphatic perhaloalkene having from 2 to 12 carbon atoms and a fluorine atom on at least each of the carbon atoms connected by the double bond, said polymer having as a repeating unit wherein R is a divalent radical selected from the group consisting of wherein X is a halogen selected from the group consisting of fluorine, chlorine, bromine, iodine, or any stable combination thereof within the same molecule; N IS AN INTEGER OF FROM 1 TO 4; Y IS AN INTEGER OF FROM 0 TO 10; AND Z IS AN INTEGER OF FROM 0 TO (10-Y).
[参考文献]: Ben-Zhan Zhu, Et Al. Molecular Mechanism For Metal-Independent Production Of Hydroxyl Radicals By Hydrogen Peroxide And Halogenated Quinones. Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17575-8. [参考文献]: C Den Besten, Et Al. Cytochrome P450-Mediated Oxidation Of Pentafluorophenol To Tetrafluorobenzoquinone As The Primary Reaction Product. Chem Res Toxicol. 1993 Sep-Oct;6(5):674-80. [参考文献]: Suping Jia, Et Al. Detection And Mechanistic Investigation Of Halogenated Benzoquinone Induced Dna Damage By Photoelectrochemical Dna Sensor. Anal Bioanal Chem. 2010 Jul;397(6):2395-400.
合成参考文献
摘要:Bredenkamp, A.; Kirsch, S. F., Science of Synthesis Knowledge Updates, (2014) 4, 425. 参考文献:10.2116/analsci.18.851 摘要:Zhong JC, Maekawa M, Kuroda-Sowa T, Suenaga Y, Ohta T, Munakata M. Crystal structure of 1:1 donor-acceptor complex between 9,10-benzophenanthrene and 2,3,5,6-tetrafluoro-1,4-benzoquinone. Anal Sci. 2002 Jul;18(7):851–2. doi: 10.2116/analsci.18.851.