CAS: 5000-66-8; 2-Bromo-1-(2-Chlorophenyl)Ethanone

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CAS号2142-68-9 邻氯苯乙酮 | CAS号1056775-36-0 1-(bromoethynyl... | CAS号186581-53-3 重氮甲烷 | CAS号609-65-4 邻氯苯甲酰氯 | CAS号1050507-06-6 4-(2-氯苯基)-2-噻唑羧酸乙酯 | CAS号40018-25-5 邻氯苯乙酰腈 | CAS号743357-99-5 2-氨基-2'-氯苯乙酮 | CAS号21344-90-1 2-氨基-4-(2-氯苯基)噻唑 | CAS号72702-57-9 Alpha-溴甲基-2-氯苯甲醇 | CAS号777853-12-0 4-(2-氯苯基)-2-甲基噻唑 | CAS号60850-73-9 1-(2-氯苯基)-2-(1H...

1-(2-氯苯基)乙醇置于氢溴酸,双氧水体系中,用 水,乙腈 作为反应溶剂,化学反应 6.0H,以52%的收率获得产物2-溴-2'-氯苯乙酮
参考文献:H2O2/hbr 系统-多个方向,但一个选择:氧化-将仲醇溴化为单溴酮或二溴酮†
标题:H2O2/hbr 系统-多个方向,但一个选择:氧化-将仲醇溴化为单溴酮或二溴酮†
摘要:在这项工作中,我们发现H2O 2-hbr(Aq)系统可以从脂肪族和仲苄醇合成α-一溴酮和α,α'-二溴酮,收率高达91%.通过改变过氧化氢和氢溴酸的量,可以选择性地引导该过程形成单溴酮或二溴酮.应用方便,设备简单,反应活性多方面以及符合绿色化学原理,使得H2O 2-hbr(Aq)系统的应用在实验室和工业界非常有吸引力.尽管已知酮具有通过baeyer-Villiger反应氧化或在过氧化氢和布朗斯台德酸存在下形成具有o-O部分的化合物过氧化的已知特性,但所提出的氧化-溴化过程是选择性的.
DOI:10.1039/c8Ra04885A

专利信息

专利号:US-4314066-A
优先权日:1976-11-08
标题 :Synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

专利号:US-4370482-A
优先权日:1978-02-15
标题:Synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazols, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

专利号:US-4310672-A
优先权日:1976-04-26
标题 :Synthesis of intermediates for tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, di-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

专利号:US-4620009-A
优先权日:1980-03-17
标 题 :Synthesis of intermediates for tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:CYANAMID AGRICULTURAL DE PUERT
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

专利号:US-4139707-A
优先权日:1976-11-08
标题 :Intermediates for synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

专利号:US-4090025-A
优先权日:1976-04-26
标题 :Intermediates for synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR KENTARO; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.