CAS: 4769-73-7; 1-Chloro-3-Phenoxypropan-2-Ol

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📜烯丙基苯基醚置于μ-(R)-Binap μ-1-Phenylhexane-1,3,5-Triketone Bis[(Acetonitrile)Palladium(II)] Tetrafluoroborate,氧气,Lithium Chloride,Copper Dichloride体系中,用 四氢呋喃,水 作为反应溶剂,23.0 °C,101.33 Kpa 条件下,反应 120.0H,以40%的收率获得产物1-氯-3-苯氧基-2-丙醇
参考文献:催化,对映选择性烯烃二溴化和氯羟化反应的再研究
标题:催化,对映选择性烯烃二溴化和氯羟化反应的再研究
摘要:描述了从经常引用的文献研究中尝试再现八种推定的,对映选择性的二溴化和氯羟基化反应的尝试.反应尽可能完全按照原始报告进行.对映体组成的分析是通过手性固定相HPLC或sfc(csp-HPLC或csp-Sfc)进行的,与原始报告相反,该报告使用了手性位移试剂NMR光谱.经过仔细研究,发现报告的对映选择性水平不正确.讨论了假阳性结果的可能解释.
DOI:10.1021/acs.Orglett.5B02650

专利信息

专利号:US-4322557-A
优先权日:1981-02-17
标题:1-Aryloxy-2-(S)-hydroxy-3-(triarylphosphonio)-propane derivatives as prostaglandin intermediates
发明人：ANDREWS GLENN C
权利人:PFIZER
摘要:1-Aryloxy-2-(S)-hydroxy-3-(triarylphosphonio)-propane salts and alkali metal ylids thereof are novel intermediates useful in the direct synthesis of 15-(R)-hydroxy-16-aryloxy-prostaglandins.

专利号:US-7005282-B2
优先权日:2002-01-14
标 题:Enzymes coated with ionic liquid
发明人：KIM MAHN-JOO; LEE JAE KWAN
权利人:POSCO AND POSTECH FOUNDATION
摘要:Disclosed is an ionic liquid-coated enzyme, wherein the ionic liquid is an organic salt which presents as a liquid phase at a temperature of about 150° C. or below. The ionic liquid-coated enzyme according to the present invention remarkably improves enzyme functions, such as enantioselectivity and stability, when the enzyme which may be lipase is coated with an ionic liquid. Further, even in the case of when the ionic liquid-coated enzyme is reused, the enantiomeric excess, enantioselectivity, and activity are not degenerated. The coated enzyme is usable as a catalyst for providing a chiral intermediate required in the synthesis of chiral pesticides, medicines, natural chemicals, and so on.

专利号:US-4356322-A
优先权日:1977-12-01
标题 :Phenoxyalkanolamine derivatives
发明人：LEHMANN DIETER; FEMMER KLAUS; FAUST GOTTFRIED
权利人:DRESDEN ARZNEIMITTEL
摘要:A series of novel derivatives of phenoxyalkanolamine of the general formula: ##STR1## wherein R 1 , R 2 and R 3 are the same or different and are hydrogen, alkyl of 1 to 2 carbon atoms, methoxy, halogen, nitro, amino or acylamino residues, and the salts thereof, are described, as are methods for their synthesis. The compounds are highly active β 1 -specific sympathicomimetics with a partially antagonistic component.