CAS: 4377-35-9; 2-(Dichloromethyl)Pyridine

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CAS号4377-37-1 2-(trichloromet... | CAS号109-06-8 2-甲基吡啶 | CAS号274-59-9 [1,2,3]三唑并[1,5-a]吡啶 | CAS号20979-34-4 2-(chloromethyl... | CAS号1121-60-4 吡啶-2-甲醛 | CAS号4377-37-1 2-(trichloromet...

📜2-(三氯甲基)吡啶置于盐酸,丙酮,Tin(Ll) Chloride体系中,化学反应生成 2-(二氯甲基)吡啶
参考文献:162. ω-Trichloro-和ω-二氯-α甲基吡啶
标题:162. ω-Trichloro-和ω-二氯-α甲基吡啶
摘要:
DOI:10.1039/jr9390000781

专利信息

专利号:US-7355036-B2
优先权日:2001-07-03
标 题 :Two-stage protective groups for the synthesis of biopolymers
发明人：GUEIMIL RAMON; SCHEFFLER MATTHIAS; STAEHLER PEER F; BEIJER BARBRO
权利人:FEBIT AG
摘要:The invention relates to a method for the synthesis of a nucleic acid by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups. The two-stage protective groups are split by means of a first exposure step and a subsequent chemical treatment step

专利号:WO-9616071-A1
优先权日:1994-11-21
标题:PROCESSES FOR THE SYNTHESIS OF 3'-SUBSTITUTED LEWISx COMPOUNDS
发明人：SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
权利人:GLYCOMED INC; SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
摘要:Disclosed are processes for the chemical synthesis of 3'-substituted Lewis-OR compounds where R is an aglycon of at least one carbon atom. One particular compound prepared by the processes of this invention is 8-methoxycarbonyl-octyl-2-acetamido-3-O-( alpha -L-fucopyranosyl)-4-O-[3-O-sulfo- beta -D-galactopyranosyl]-2-deoxy- beta -D-glucopyranoside.

专利号:US-8710210-B2
优先权日:2010-06-30
标题:Method of using N-thio compounds for oligonucleotide synthesis
发明人：HE YIGANG; SOROKIN VICTOR; MAZUR WIESLAW ADAM
权利人:HE YIGANG; SOROKIN VICTOR; MAZUR WIESLAW ADAM; GIRINDUS AMERICA INC
摘要:A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R 1 and R 2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.

专利号:US-7019127-B2
优先权日:1997-08-13
标 题 :Solution phase synthesis of oligonucleotides
发明人：REESE COLIN BERNARD; SONG QUANLAI
权利人:AVECIA LTD
摘要:A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent to form an H-phosphonate diester. The H-phosphonate diester is oxidised in situ with a sulfur transfer agent to produce the phosphorothioate triester. Preferably, the H-phosphonate and alcohol are protected nucleosides or oligonucleotides. Oligonucleotide H-phosphonates which can be used in the formation of phosphorothioate triesters are also provided.

专利号:US-7923584-B2
优先权日:2008-01-23
标题 :Synthesis of difunctional oxyethylene-based compounds
发明人：HOLMES BRIAN T; SNOW ARTHUR W
权利人:US NAVY
摘要:A method of reacting a toluenesulfonyl-terminated polyoxyethylene compound having the formula CH 3 —C 6 H 4 —SO 2 —(O—CH 2 —CH 2 ) n —O—R 1 with an ammonium salt having the formula NR 2 4 X to form a compound having the formula X—CH 2 —CH 2 —(O—CH 2 —CH 2 ) n-1 —R 3 . The value n is a positive integer. X is a halogen, cyanide, cyanate, thiocyanate, or azide. R 1 is a terminating group. Each R 2 is hydrogen or an alkyl group. —R 3 is —O—R 1 or —X.

专利号:US-5498786-A
优先权日:1991-01-31
标 题 :Synthesis of intermediates in the preparation of ACAT inhibitors
发明人：KELLY SARAH E; CHANG GEORGE
权利人:PFIZER
摘要:This invention relates to novel processes for synthesizing intermediates in the preparation of N-aryl and N-heteroarylamide inhibitors of the enzyme acyl coenzyme A: cholesterol acyltransferase (ACAT), and to novel intermediates used in such processes.