CAS: 400-99-7; 2-Nitro-4-(Trifluoromethyl)Phenol

上下游产品

2-chloro-3-nitro-5-trifluoromethylbenzene 4-trifluoromethyl-2-nitroaniline zephirol 2-methoxy-ethanol 2-amino-4-(trifluoromethyl)phenol α,α,α-Trifluoro-2,6-dinitro-p-cresol α,α,α-Trifluor-6'-hydroxy-m-formyltoluidin 2-Nitro-4-trifluormethylphenyl ethyl carbonat

对三氟甲基苯酚置于iron(Iii) Nitrate Nonahydrate,六氟异丙醇体系中,用85 %的收率获得产物4-羟基-3-硝基三氟甲苯
参考文献:Fe(No3)3.9H2O 在六氟异丙醇中对未活化芳烃进行后期 C-H 硝化
标题:Fe(No3)3.9H2O 在六氟异丙醇中对未活化芳烃进行后期 C-H 硝化
摘要:使用廉价且易于获得的化学品进行操作简单且普遍适用的芳烃硝化一直是合成有机界长期以来寻求的转变.在这项工作中,我们以无毒且廉价的fe(No 3) 3 .9H2O作为硝基源,并通过氢键相互作用网络以易于回收的溶剂六氟异丙醇作为促进剂实现了这一目标.由于该方案相对温和且可靠性高,实现了各种高功能化天然产物和市售药物的后期硝化.
DOI:10.1021/acs.Orglett.4C01006

专利信息

专利号:US-7807821-B1
优先权日:2004-03-01
标题 :Method for the synthesis of nucleic acid without protecting base moiety
发明人：SEKINE MITSUO; SEIO KOHJI; OHKUBO AKIHIRO
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:A phosphoramidite method for the synthesis of a nucleic acid oligomer without protecting the base moiety characterized in that a 3′ or 5′ hydroxyl group of a nucleotide is reacted with a nucleoside phosphoramidite, a cyclonucleoside phosphoramidite, a 2′-substituted nucleoside phosphoramidite, a 4′-substituted nucleoside phosphoramidite, or a 2′,4′-di-substituted nucleoside phosphoramidite to produce a phosphodiester linkage. The phosphoramidite is contacted with an activator containing both a) hydroxybenzotriazole-1-ol (HOBt), a mono-substituted HOBt, a di-substituted HOBt, or a di-substituted phenol and b) imidazole, tetrazole, benzimidazoletriflate (BIT), 4-ethylthiotetrazole, imidazolium triflate(trifluoromethane sulfonate) or 4,5-dicyanoimidazole.

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

专利号:CN-118388379-A
优先权日:2024-04-19
标题 :Organic total synthesis method of nimesulide derivative