专利号:US-5218088-A 优先权日:1989-11-02 标 题 :Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates 发明人:GORENSTEIN DAVID; FARSCHTSCHI NASSAR 权利人:PURDUE RESEARCH FOUNDATION 摘要:A method for synthesis of oligonucleotide analogs having dithiophosphate internucleosidic linkages is described. Monohalohydrocarbylthiophosphoramidites are utilized to prepare nucleoside thiophosphoramidite intermediates which are activated for nucleoside coupling with tetrazole catalysts. Sulfur oxidation and dehydrocarbylation of the coupled thiophosphite intermediates provide oligonucleotide analogs having achiral dithiophosphate internucleosidic linkages.
专利号:US-7256177-B2 优先权日:2003-06-17 标题 :Lincomycin derivatives possessing antibacterial activity 发明人:LEWIS JASON G; ANANDAN SAMPATH K; O'DOWD HARDWIN; GORDEEV MIKHAIL F 权利人:VICURON PHARM INC 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
专利号:US-7361743-B2 优先权日:2004-02-11 标 题 :Lincomycin derivatives possessing antibacterial activity 发明人:LEWIS JASON G; ANANDAN SAMPATH K; O'DOWD HARDWIN; GORDEEV MIKHAIL F; LI LIANSHENG 权利人:PFIZER 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
专利号:US-7199106-B2 优先权日:2003-06-17 标题 :Lincomycin derivatives possessing antimicrobial activity 发明人:LEWIS JASON G; ANANDAN SAMPATH-KUMAR; O'DOWD HARDWIN; GORDEEV MIKHAIL F 权利人:VICURON PHARM INC 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.