CAS: 38512-82-2; 2-Methoxy-4-Methyl-1-Nitrobenzene

该化合物是一种硝化化合物,其特点是在5位置有一组甲基化合物,在2位置有一组硝基化合物,在Anisole环有2位置有2位置.这种黄色晶状固体主要用作有机合成的中间体,特别是在染料,药品和农用化学品生产中.其定义明确的结构和活性使其对电益替代反应和进一步功能化很有价值.该化合物在有机溶剂中表现出中等溶解性,便于其在各种反应条件下使用.在标准储存条件下,其稳定性确保了合成应用的一贯性能.在处理过程中,由于潜在的刺激性特性,应当谨慎行事.

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上下游产品

diazomethane 2-nitro-5-methylphenol 3,4-Dinitrotoluene sodium methylate (E)-3,3'-dimethoxy-4,4'-dinitrostilbene 2-methoxy-4-methylaniline 4-amino-3-methoxybenzaldehyde 5-methyl-2-nitroaniline

合成工艺路线路线简述

    📜2,3,4,6-四溴间甲酚置于三氯化铝,甲基4-羟基-2-甲氧基-6-甲基-苯甲酸酯,硝酸,Potassium Carbonate,溶剂黄146,Copper(II) Oxide体系中,用 N,N-二甲基甲酰胺,苯 作为反应溶剂,化学反应 34.5H,反应生成 5-甲基-2-硝基苯甲醚
    参考文献:Carvalho,Christopher F.; Sargent,Melvyn V.,Journal Of The Chemical Society. Perkin Transactions I,1984,# 7,P. 1613-1620
    标题:Carvalho,Christopher F.; Sargent,Melvyn V.,Journal Of The Chemical Society. Perkin Transactions I,1984,# 7,P. 1613-1620

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    专利信息


    专利号:WO-9729091-A1
    优先权日:1996-02-09
    标题:Balanol analogues
    发明人：NIELSEN JOHN; LYNGSOE LARS OLE
    权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE
    摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.

    专利号:US-9133224-B2
    优先权日:2010-11-29
    标 题:Macrocyclic kinase inhibitors
    发明人：CREW ANDREW P; DONG HANQING; FERRARO CATERINA; SHERMAN DAN; SIU KAM W
    权利人:CREW ANDREW P; DONG HANQING; FERRARO CATERINA; SHERMAN DAN; SIU KAM W; OSI PHARMACEUTICALS LLC
    摘要:Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial.

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    合成参考文献


    参考文献:10.1007/978-1-4020-9787-4_22
    摘要:Martin R. Addendum 2005–2008. 2011. In: Aromatic Hydroxyketones: Preparation and Physical Properties.
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