CAS: 330784-47-9; (S)-4-((3-Chloro-4-Methoxybenzyl)Amino)-2-(2-(Hydroxymethyl)Pyrrolidin-1-yl)-N-(Pyrimidin-2-Ylmethyl)Pyrimidine-5-Carboxamide

上下游产品

4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid 2-aminomethylpyrimidine 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-hydroxybenzylamino)-5-[N-(2-pyrimidylmethyl)carbamoyl]pyrimidine

在 Sodium Tetrahydroborate,Potassium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,以40 G的收率获得阿伐那非
参考文献: A Process For The Preparation Of Avanafil And Its Novel Intermediates[fr] Procédé De Préparation D'Avanafil Et De Ses Nouveaux Intermédiaires
标题: A Process For The Preparation Of Avanafil And Its Novel Intermediates[fr] Procédé De Préparation D'Avanafil Et De Ses Nouveaux Intermédiaires
摘要:本发明涉及一种新型的化合物(II)及其在阿伐那非制备中的应用,[应在此处插入公式]其中r为-Oh,-Ci或-Or1,R1为c1到c3烷基.

专利信息

专利号:WO-2022244943-A1
优先权日:2021-05-21
标题 :Method for predicting recurrence of lung cancer, and pharmaceutical composition for recurrence inhibition
发明人：LEE HO-YOUNG
权利人:SEOUL NAT UNIV R&DB FOUNDATION
摘要:The present invention relates to: a method for providing information necessary in predicting the recurrence of lung cancer; a pharmaceutical composition for inhibiting the recurrence of lung cancer; and the like. Since the present inventors have identified that in slow-cycling cancer cells responsible for lung cancer recurrence, RGS2 is significantly increased and ATF4 is reduced, it is expected that by measuring the level of expression or activity of RGS2 and ATF4, the likelihood of lung cancer recurrence can be easily and quickly predicted. In addition, since the present inventors have identified that the growth of slow-cycling cancer cells can be inhibited and the apoptosis thereof can be induced by eliminating the expression of RGS2 or blocking the protein synthesis inhibitory action of RGS2, the present invention is expected to be also variously usable in the drug development of lung cancer recurrence inhibiting therapeutic agents for inhibiting the expression or activity of RGS2.

专利号:WO-2024258389-A1
优先权日:2023-06-13
标 题 :Magnetic erector device
发明人：AÅžCI HALIL; ÇÖMLEKÇİ SELÇUK; YILDIRIM BAÅž FUNDA; SAVRAN MEHTAP; KÜÇÜKKEBABCI GÖRKEM; TANER RÃœMEYSA
权利人:SUELEYMAN DEMIREL UENIVERSITESI IDARI VE MALI ISLER DAIRE BASKANLIGI GENEL SEKRETERLIK
摘要:The invention relates to a low-cost magnetic erector device that increases nitric oxide production via endothelial nitric oxide synthase from the endothelial layer, the innermost layer of the vascular structure, in the area where it is applied in vitro, without contact and without containing chemicals, increases the blood circulation of the tissue in the area where it is applied and also provides the possibility of repeated use and portable usability by means of its in vitro activity, contributes to vasodilatation in the area where it is applied with pulsed electromagnetic field (PEMF) and increases the synthesis of tissue growth factors such as vascular endothelial growth factor, does not cause painful stimuli and the power, frequency and duration of which can be adjusted.

专利号:EP-4630405-A1
优先权日:2022-12-06
标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2024123815-A1
优先权日:2022-12-06
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:CA-2966800-A1
优先权日:2014-11-07
标 题:Synthesis of copanlisib and its dihydrochloride salt