CAS: 286930-02-7; (R)-2-(3-(Diisopropylamino)-1-Phenylpropyl)-4-(Hydroxymethyl)Phenyl Isobutyrate

上下游产品

CAS号1390644-37-7 (R)-2-(3-(diiso... | CAS号1390644-50-4 (R)-2-(3-(diiso... | CAS号1390644-52-6 2-((R)-3-(diiso... | CAS号97-72-3 异丁酸酐 | CAS号207679-81-0 (R)-5-羟甲基托特罗定 | CAS号79-30-1 异丁酰氯 | CAS号1206695-46-6 Fesoterodine L-... | CAS号156755-35-0 3-[(1R)-3-[双(1-... | CAS号156755-23-6 6-溴-3,4-二氢-4-苯基...

📜2-((R)-3-(Diisopropylamino)-1-Phenylpropyl)-4-(Hydroxymethyi)Phenyl-3-Bromo-2-Methyl Propanoate置于palladium 10% On Activated Carbon Sodium Acetate,氢气体系中,用 水,乙酸乙酯 用作溶剂,25.0~30.0 °C,392.27 Kpa 条件下,反应 12.5H,反应生成弗斯特罗定
参考文献: Process For The Preparation Of Muscarinic Receptor Antagonist[fr] Procédé De Préparation De L'Antagoniste Du Récepteur Muscarinique
标题: Process For The Preparation Of Muscarinic Receptor Antagonist[fr] Procédé De Préparation De L'Antagoniste Du Récepteur Muscarinique

专利信息

专利号:WO-2023166184-A1
优先权日:2022-03-03
标题 :Catalytically active material for ammonia synthesis obtainable by reduction of a precursor material having a phase pure spinel structure
发明人：RULAND HOLGER; FOLKE JAN; REIN DENISE; ORTEGA KLAUS FRIEDEL; BEHRENS MALTE; SCHLÖGL ROBERT
权利人:FRITZ HABER INST DER MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a catalytically active material for ammonia synthesis obtainable by reducing a precursor material having a phase pure spinel structure which itself is obtainable by heating an intermediate having a layered double hydroxide (LDH) structure. The present invention is also directed to a method of forming the catalytically active material and to a method of synthesizing ammonia, decomposing ammonia or both when using the catalytically active material. Moreover, the present invention is concerned with the use of the catalytically active material in the synthesis of ammonia, decomposition of ammonia or both as well as the use of the intermediate and the precursor material in the preparation of the catalytically active material for ammonia synthesis.

专利号:WO-2017137955-A1
优先权日:2016-02-14
标题:Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol
发明人：THOMBARE PRAVIN SAHADEV
权利人:CELESTIS PHARMACEUTICALS PVT LTD
摘要:The present invention relates to novel chiral 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine (5) and racemic 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine () and its use in improved and industrially advantageous process for preparation of chiral and racemic form of 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol. Further, present invention relates to preparation of the same.

专利号:EP-1862449-A1
优先权日:2006-05-31
标 题 :A shortened synthesis of substituted hydroxymethyl phenols
发明人：BROWNE ROISIN; KIKELLY MICHAEL
权利人:SCHWARZ PHARMA LTD
摘要:The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol or its phenolic monoesters or salts thereof, characterized by the steps of na) reacting a compound of formula (II)n nwith a mixture of MeMgCl and Mg in a solvent, nb) optionally reducing the temperature of the Grignard reagent to a lower temperature than in step a), and n nreacting the resulting Grignard reagent with an excess of a carbonate in a solvent, to obtain a compound of formula (III)n nwherein A is a C 1 -C 6 alkyl group, and then further reacting the compound of formula (III) in a known manner to obtain the desired end product.

专利号:US-8299306-B2
优先权日:2006-06-08
标 题 :Accelerated synthesis of substituted hydroxymethyl phenols
发明人：ENNIS SETH C; KENNEDY BRYAN D
权利人:ENNIS SETH C; KENNEDY BRYAN D
摘要:This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C 1 -C 6 alkyl-carbonyl group or a phenylcarbonyl group, or a salt thereof, comprising the following steps: a) adding to a suspension of Mg a compound of formula (II) R 1 (MgX) n —LiY wherein n is 1 or 2; R 1 is an aromatic, aliphatic, carbocyclic or heterocyclic organic group having 1 to 24 carbon atoms; X and Y are independently selected from Cl, Br and I, b) reacting said reaction mixture with a suitable halogenated compound in a solvent to form a Grignard reagent, c) reacting said Grignard reagent with a suitable linear, branched or cyclic carbonate to obtain a compound of formula (IV) wherein A is a linear, branched or cyclic C 1 -C 6 alkyl group, and preferably a methyl group, and then further reacting the compound of formula (IV) in a known manner to obtain a compound of formula (I) and optionally salt formation.

专利号:US-8703996-B2
优先权日:2010-03-09
标题:Short synthesis of tolterodin, intermediates and metabolites
发明人：STERK DAMJAN
权利人:STERK DAMJAN; LEK PHARMACEUTICALS
摘要:A process is described for the preparation of intermediates which can be used for preparation of agents for urinary incontinence therapy, specifically to 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol and its prodrugs.

专利号:US-7985873-B2
优先权日:2006-06-09
标题:Synthesis of phenolic esters of hydroxymethyl phenols
发明人：ENNIS SETH C; DREWS ROLAND; MEESE CLAUS
权利人:UCB PHARMA GMBH
摘要:The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C 1 -C 6 alkyl group or an aryl group which may optionally be substituted. This process comprises: (a) reacting a compound of formula (II), with a compound of formula (III), wherein R is as defined above and X is a leaving group, in the presence of N,N-di-isopropylethylamine.