专利号:US-10633360-B2 优先权日:2014-12-23 标题 :Efficient process for the synthesis of alkoxy substituted benzaldehydes 发明人:MOHAPATRA Manoj Kumar; BENDAPUDI Ramamohanrao; MENACHERRY Paul Vincent; PAUL VINCENT 权利人:ANTHEA AROMATICS PRIVATE LTD 摘要:The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as end products and intermediates in flavor and fragrance applications and pharmaceutical ingredients. For example, 3,4-methylendioxy-benzaldehyde (also known as heliotropin or piperonal) is used widely both as a end product and intermediate for the above mentioned applications. Other examples include 3,4-dimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and 3,4-ethylenedioxybenzene which are intermediates in the synthesis of active pharmaceutical intermediates.
专利号:US-2015336866-A1 优先权日:2013-01-01 标题:Synthesis of difluoromethyl ethers and sulfides 发明人:HARTWIG JOHN; FIER PATRICK 权利人:UNIV CALIFORNIA 摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.
专利号:US-2023346952-A1 优先权日:2015-09-22 标题:Cannabinoid glycoside prodrugs and methods of synthesis 发明人:ZIPP BRANDON J; HARDMAN JANEE’ M; BROOKE ROBERT T; DEUTSCHER TYREL R 权利人:GRAPHIUM BIOSCIENCES INC 摘要:The present invention provides tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs and pharmaceutical compositions comprising these compounds, and their use for the site-specific delivery of tetrahydrocannabinol or cannabidiol. Also provided are processes for the preparation of purified tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs.
专利号:US-2014336259-A1 优先权日:2011-06-10 标 题:Phenolic compounds with antioxidant and anti-cancer properties, analogs and synthesis thereof 发明人:SEERAM NAVINDRA; BARBEAU JULIE; BELAND GENEVIEVE; PARANG KEYKAVOUS 权利人:SEERAM NAVINDRA; BARBEAU JULIE; BELAND GENEVIEVE; PARANG KEYKAVOUS 摘要:The present document describes a phytochemical isolated from maple syrup and composition comprising the same. More specifically, the document describes an antioxidant phytochemical compound, derivates thereof, and composition comprising the same. The document also describes a process of synthesizing the antioxidant phytochemical compound.
专利号:US-2017349566-A1 优先权日:2014-12-23 标 题 :An efficient process for the synthesis of alkoxy substituted benzaldehydes
专利号:WO-2017053574-A1 优先权日:2015-09-22 标题 :Cannabinoid glycoside prodrugs and methods of synthesis