CAS: 2447-79-2; 2,4-Dichlorobenzamide

该化合物其结构特征为:以2和4个位置上的两个氯原子和一个氨化功能组取代一个苯环,它是在有机溶剂中可溶解但水溶性有限的一种白到白的晶状固体,该化合物主要用于农业用途,作为除草剂,特别是用于控制作物中的某些杂草,其行动方式包括抑制植物中的特定生物化学途径,导致生长中断. 2,4-二氯苯甲酰胺也对环境研究感兴趣,因为它在土壤和水中具有潜在的持久性,引起了人们对其生态影响的关切.安全数据表明,如果管理不当,它可能会对人类健康和环境造成风险,因此应当谨慎地加以处理.

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CAS号874-42-0 2,4-二氯苯甲醛 | CAS号56843-28-8 2,4-二氯苯甲醛肟 | CAS号89-75-8 2,4-二氯苯甲酰氯 | CAS号6574-98-7 2,4-二氯苯腈 | CAS号2234-16-4 2,4-二氯苯乙酮 | CAS号126-81-8 醛试剂 | CAS号73339-77-2 N,N'-bis-(2,4-d... | CAS号120-46-7 二苯甲酰甲烷 | CAS号123-54-6 乙酰丙酮 | CAS号50-84-0 2,4-二氯苯甲酸 | CAS号23589-75-5 5-(2,4-dichloro... | CAS号2234-16-4 2,4-二氯苯乙酮 | CAS号2775-38-4 2,4-二氯苯硫酰胺 | CAS号6574-98-7 2,4-二氯苯腈 | CAS号619-56-7 4-氯苯甲酰胺 | CAS号2612-57-9 2,4-二氯苯基异氰酸酯 | CAS号65675-97-0 2,4-dichloro-N-...

合成工艺路线路线简述

    📜2,4-二氯苯甲酸置于氯化亚砜,Ammonium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应 1.08H,以83%的收率获得2,4-二氯苯甲酰胺
    参考文献:钯催化伯酰胺脱水形成腈的开发和利用.
    标题:钯催化伯酰胺脱水形成腈的开发和利用.
    摘要:在selectfluor的存在下,钯(II)催化剂可将伯酰胺高效且化学选择性地转化为腈.酰胺可以连接到芳环,杂芳环或脂族侧链上,并且该反应可耐受空间体积和电子修饰.含有三个谷氨酰胺基团的肽醇的脱水为每个谷氨酰胺残基提供了构效关系.因此,这种脱水可以通过合成突变与谷氨酰胺的丙氨酸扫描相似.
    Doi:10.1021/acs.Orglett.8B02422

    海关参考信息

    专利信息


    专利号:US-4536599-A
    优先权日:1978-08-22
    标题:Synthesis of amine derivatives
    发明人：MASUKO FUJIO; KATSURA TADASHI
    权利人:SUMITOMO CHEMICAL CO
    摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

    专利号:US-12180188-B2
    优先权日:2020-05-19
    标题:Antifibrotic compounds and related methods
    发明人：STEFANOVIC BRANKO; NEFZI ADEL
    权利人:UNIV FLORIDA STATE RES FOUND; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
    摘要:This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.

    专利号:EP-0040896-B1
    优先权日:1978-08-22
    标题:Synthesis of amides

    专利号:EP-0008532-A1
    优先权日:1978-08-22
    标 题 :Synthesis of amines

    专利号:EP-0040896-A2
    优先权日:1978-08-22
    标 题 :Synthesis of amides

    专利号:CN-103626816-A
    优先权日:2013-12-13
    标题 :Synthesis method and antibacterial application of acetylglucosamine imidazole-2,4,5-trione

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    合成参考文献


    摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 80.
    参考文献:10.1021/jm901788j
    摘要:McHardy T, Caldwell JJ, Cheung K, Hunter LJ, Taylor K, Rowlands M, Ruddle R, Henley A, de Haven Brandon A, Valenti M, Davies TG, Fazal L, Seavers L, Raynaud FI, Eccles SA, Aherne GW, Garrett MD, Collins I. Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt). J. Med. Chem. 2010 Feb 12;53(5):2239–49. doi: 10.1021/jm901788j.
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