CAS: 23316-67-8; (2R,3R,4S,5S)-2-((Benzoyloxy)Methyl)-5-Cyanotetrahydrofuran-3,4-Diyl Dibenzoate
该化合物是一种化学化合物,属于核糖衍生物类别,其特点是一种核糖糖糖混合物,在2',3'和5'的位置上由苯并硫基组充分保护,这加强了其在有机溶剂中的稳定性和溶解性;氰化物组的存在引入了一个反应功能组,使其在各种合成应用中有用,特别是在有机化学和核糖化学领域.该化合物通常用于合成更复杂的分子,包括核糖核酸和核酸类比.其结构允许特定的再活动模式,使其成为制药和生物化学开发中的宝贵中间体.此外,在温和条件下可以有选择地去除苯并保护苯并氨基组,从而推动核糖单位的进一步功能化.总体而言,2,3,5-5-Tri-O-苯-苯基-β-丁-二苯二甲基二酸基氰酸基丙酸氰化二,是合成有机化学中的一种重要化合物,特别是在核克隆合成合成合成的情况下.
- 英文名称(2R,3R,4S,5S)-2-((Benzoyloxy)Methyl)-5-Cyanotetrahydrofuran-3,4-Diyl Dibenzoate
- 中文名称1-氰基-2,3,5-三苯甲酰氧基-β-D-呋喃核糖
- IUPAC名称(2R,3R,4S,5S)-2-((benzoyloxy)methyl)-5-cyanotetrahydrofuran-3,4-diyl dibenzoate
- 其它别名Ofmytvndirtgmr-Uarrhkhwsa-; 2,3,5-Tri-O-Benzoyl-B-D-Ribofuranosylcyanide; D-Allononitrile, 2,5-Anhydro-, 3,4,6-Tribenzoate; (2S,3S,4R,5R)-4-(Benzoyloxy)-5-[(Benzoyloxy)Methyl]-2-Cyan
- CAS编号23316-67-8
- MFCD编号:MFCD00136146
- EINECS号:622-815-6
- 分子式:C27H21NO7
- 分子量:471.46
- 产品CID: 1174902
- 产品分类生物化工 → 核苷类药物 → 核苷中间体
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
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1-乙酰氧基-2,3,5-三苯甲酰氧基-1-Beta-D-呋喃核糖 反应生成1-氰基-2,3,5-三苯甲酰氧基-Beta-D-呋喃核糖
参考文献:Tetrahedron Lett 2002,43,6561-6562
标题:Tetrahedron Lett 2002,43,6561-6562
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:EP-0804447-A1
优先权日:1995-03-07
标题 :Procedures for obtaining ribo-c-nucleosides
发明人：LEWIS ARTHUR F; ROBINS ROLAND K; RAJU NATARAJAN; BHARADWAJ RAMESH; PEJANOVIC VJERA; RAMASAMY KANDASAMY
权利人:ICN PHARMACEUTICALS
摘要:Novel procedures for obtaining ribo-C-nucleosides, including especially 2-β-D-ribofuranosylthiazole-4-carboxylamide (tiazofurin) and 2-β-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures involve introducing a cyano group at the (1') position of a ribose, directly or indirectly converting the cyano group to HN=C-OR1 or thicarboxylamide wherein R1 is a lower alkyl, forming the group which substituted for the cyano group into a heterocyclic ring containing an ester, and converting the ester into an amide.
专利号:US-5907036-A
优先权日:1995-02-17
标题 :Procedures for obtaining ribo-C-nucleosides
发明人：RAMASAMY KANDASAMY; LEWIS ARTHUR F; ROBINS ROLAND K; RAJU NATARAJAN; BHARADWAJ RAMESH; PEJANOVIC VJERA
权利人:ICN PHARMACEUTICALS
摘要:Novel procedures for obtaining ribo-C-nucleosides, including especially 2-β-D-ribofuranosylthiazole-4-carboxylamide (tiazofirin) and 2-β-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures involve introducing a cyano group at the 1' position of a ribose, directly or indirectly converting the cyano group to HNâ•?C--OR 1 or thicarboxylamide wherein R 1 is a lower alkyl, forming the group which substituted for the cyano group into a heterocyclic ring containing an ester, and converting the ester into an amide.
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合成参考文献
参考文献:10.1128/aac.45.7.1943-1946.2001
摘要:Orme I; Tuberculosis Drug Screening Program. Search for new drugs for treatment of tuberculosis. Antimicrob Agents Chemother. 2001 Jul;45(7):1943–6.
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