CAS: 19810-31-2; 2-(Benzyloxy)Acetyl Chloride

上下游产品

CAS号30379-55-6 苄氧乙酸 | CAS号100-51-6 苯甲醇 | CAS号79-37-8 草酰氯 | CAS号32122-09-1 苄氧基乙酸乙酯 | CAS号144192-68-7 S-phenyl 2-phen... | CAS号236110-81-9 (S)-(+)-4-Benzy... | CAS号60656-87-3 苄氧基乙醛 | CAS号102616-13-7 (2E,4R,5R,6R,7E... | CAS号102616-19-3 [(Z)-dec-2-en-4... | CAS号102616-20-6 methyl (E,2R,3R... | CAS号102616-10-4 [(Z)-6-methylhe... | CAS号102616-15-9 methyl (2R,3S,4... | CAS号102616-22-8 (2E,4R,5R,6R,7E... | CAS号31600-43-8 苄氧乙酸甲酯

2-苄氧基-1,3-丙二醇置于氯化亚砜,氧气,Sodium T-Butanolate体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 22.0H,反应生成苄氧基乙酰氯
参考文献:甘油转化为高价值化学品:利用自然资源合成非天然α-氨基酸的含义
标题:甘油转化为高价值化学品:利用自然资源合成非天然α-氨基酸的含义
摘要:甘油衍生物是一类重要的化合物,作为有机合成中的基本结构基石具有很大的应用前景.使用nao T Bu-O 2系统将o-苄基甘油氧化以高收率生产高价值的化合物.此外,通过将其转化为非天然的α-氨基酸证明了所得产物的合成效用,从而表明了甘油生物质的增值.
Doi:10.1039/c9Gc00755E

专利信息

专利号:US-8809526-B2
优先权日:2010-07-19
标题 :Synthesis of cyclopentaquinazolines
发明人：KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; DALZIEL SEAN MARK; DAPREMONT Olivier; KIM HYUNJUNG; THOMPSON ANDREW S; ZELLER JAMES ROBERT
权利人:KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; DALZIEL SEAN MARK; DAPREMONT Olivier; KIM HYUNJUNG; THOMPSON ANDREW S; ZELLER JAMES ROBERT; ONYX PHARMA INC
摘要:A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801).

专利号:US-5300638-A
优先权日:1991-07-31
标题:Asymmetric synthesis of taxol side chain
发明人：FARINA VITTORIO; HAUCK SHEILA I
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to a process for the preparation of (3R, 4S)-3-hydroxy-4-phenyl-2-azetidinone derivatives which are useful intermediates in the synthesis of taxol from baccatin III, said process comprises reacting an acyloxyacetyl halide with an imine derived from L-threonine; and to compounds of formula (III) which are produced in said process: ##STR1## wherein Ar is phenyl; R 1 is hydrogen, an acyl radical of a carboxylic acid, or a carbonic acid ester radical; R 2 is hydrogen or a carboxy protecting group; and R 3 is hydrogen or a hydroxy protecting group.

专利号:US-5656662-A
优先权日:1990-01-12
标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
发明人：MANTRI PADMAJA; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.

专利号:WO-2018108954-A1
优先权日:2016-12-12
标题 :Process for the preparation of 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol
发明人：GOSSELIN FRANCIS; LINGHU XIN
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Methods of making 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol 9, an intermediate useful for the synthesis of estrogen receptor modulating compounds are described.

专利号:US-5292891-A
优先权日:1991-02-21
标 题 :Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same and method for preparing optically active compound for synthesis of physiologically active substance and optically active intermediate compound
发明人：KANEKO CHIKARA; SATO MASAYUKI
权利人:CHISSO CORP
摘要:There are provided novel and optically active 2,2-dimethyl-1,3-dioxin-4-ones which are useful as starting materials for physiologically active compounds, functional materials or the like. Provided are optically active 5,6-epoxyhexanoic acid esters and novel optically active 6-substituted tetrahydropyran-2-one derivatives. That is, optically active 6-chloromethyltetrahydropyran-2-one can be synthesized by lactonizing optically active 2,2-dimethyl-6-(3-chloro-2-hydroxypropyl)-1,3-dioxin-4-one to form optically active 6-chloromethyltetrahydropyran-2,4-dione; reacting the thus formed compound with hydrogen in the presence of a catalyst to obtain optically active 6-chloromethyl-4-hydroxytetrahydropyran-2-one; subjecting this compound to a dehydration reaction, thereby obtaining optically active 6-chloromethyldihydropyran-2-one; reacting this compound with hydrogen in the presence of a catalyst to form optically active 6-chloromethyltetrahydropyran-2-one; and then treating this compound under basic conditions to prepare an optically active 5,6-epoxyhexanoic acid ester represented by the formula (6) ##STR1## (wherein the symbol * represents an asymmetric carbon atom, and R is a methyl group or an ethyl group).

专利号:US-6407255-B2
优先权日:1998-06-16
标题:Chemical synthesis of 1,2,4-triazolinone derivative
发明人：COTTRELL IAN FRANK; DOLLING ULF H; HANDS DAVID; WILSON ROBERT DARRIN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of morpholine derivatives of formula (I) which are useful as a therapeutic agents.