CAS: 1583-83-1; 1-(Difluoromethoxy)-4-Methylbenzene

相似化合物

706-27-4 519059-04-2 73960-07-3

上下游产品

p-cresol Chlorodifluoromethane 2,2-difluoro-2-(fluorosulfonyl)acetic acid halon-1211 4-(difluoromethoxy)benzyl bromide 2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid 2-(4-Difluoromethoxy-benzyl)-2-formylamino-malonic acid diethyl ester

4-甲基苯基甲酸酯置于五氯化磷,Triethylamine Tris(Hydrogen Fluoride)体系中,化学反应 32.0H,反应生成4-(二氟甲氧基)甲苯
参考文献:用于从苯酚和醇的芳族和脂族二氟甲基醚的使用氯/氟交换方法制备三步法
标题:用于从苯酚和醇的芳族和脂族二氟甲基醚的使用氯/氟交换方法制备三步法
摘要:二氟甲基醚是由苯酚通过它们各自的甲酸酯衍生物分三步制备的.的甲酸盐首先通过用五氯化磷转化为二氯甲基醚.然后,这些醚是诱导经历氯/氟交换,以形成相应的二氟甲基醚.氯/氟交换由或室温,用thf-5Hf或et溶剂化过程中进行3的n-3Hf作为交换介质,其中hf是氟的最终来源,或者通过在环丁砜在125°C,其中kf是氟源的直接位移过程.由一个或另一个这些过程中,几乎所有的酚和电子差富电子,可以在非常好的收益率转化为各自的二氟甲基醚.脂族醇也能够被转换为使用的et它们二氟甲基醚衍生物3的n-3Hf交换介质.
Doi:10.1016/j.Jfluchem.2014.01.018

专利信息

专利号:US-9802952-B2
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
发明人：KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

专利号:US-2016145265-A1
优先权日:2013-07-15
标题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

专利号:WO-2012041858-A1
优先权日:2010-09-30
标 题:A process for the synthesis of thio-triazolo-group containing compounds

专利号:EP-2826779-A1
优先权日:2013-07-15
标题 :Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

专利号:EP-3022208-B1
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

专利号:EP-2621922-A1
优先权日:2010-09-30
标 题:A process for the synthesis of thio-triazolo-group containing compounds