CAS: 14080-59-2; 4-Chlorothieno[2,3-D]Pyrimidine

相似化合物

18740-39-1 137240-10-9 552295-08-6

上下游产品

CAS号14080-50-3 噻吩并[2,3-d]嘧啶-4(3H)-酮 | CAS号75-09-2 二氯甲烷 | CAS号79-37-8 草酰氯 | CAS号4651-82-5 2-氨基噻吩-3-甲腈 | CAS号55654-21-2 methyl 2-formyl... | CAS号18740-26-6 (噻吩并[2,3-d]嘧啶-4... | CAS号272-24-2 噻吩并[2,3-d]嘧啶 | CAS号1217309-72-2 6-bromo-2-butyl... | CAS号56844-12-3 4-氯-6-溴噻吩并[2,3-d]嘧啶 | CAS号14080-55-8 噻吩并[2,3-d]嘧啶-4-硫醇 | CAS号14080-56-9 4-氨基噻吩并[2,3-d]嘧啶 | CAS号14080-52-5 4-甲氧基噻吩并[2,3-d]嘧啶 | CAS号86825-96-9 4-氯噻吩并[2,3-d]嘧啶-6-羧酸 | CAS号60703-80-2 6-溴噻吩并[2,3-D]嘧啶 | CAS号63893-52-7 N,N-dimethylthi...

Methyl 2-Formylaminothiophene-3-Carboxylate置于三氯氧磷体系中,化学反应 21.5H,反应生成4-氯噻吩[2,3-D]嘧啶
参考文献:微波辅助合成2-氨基噻吩-3-羧酸衍生物,3 H-噻吩并[2,3-D ]嘧啶-4-酮和4-氯噻吩并[2,3-D ]嘧啶
标题:微波辅助合成2-氨基噻吩-3-羧酸衍生物,3 H-噻吩并[2,3-D ]嘧啶-4-酮和4-氯噻吩并[2,3-D ]嘧啶
摘要:两分钟的微波辐射允许合成几种2-氨基噻吩-3-羧酸衍生物.还报道了它们在微波辐射下有效转化为噻吩并[2,3-D ]嘧啶-4-酮和相应的4-氯衍生物.
Doi:10.1016/j.Tetlet.2007.05.136

专利信息

专利号:US-2004138238-A1
优先权日:2002-08-08
标题 :Substituted aminopyrimidine compounds as neurokinin antagonists
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; KESAVAN VENKITASAMY; SHARADENDU ANURAG; MOHANTY PRADYUMNA; CHEN DONGLI; CHERUKU SRINIVASA RAO; HEIFETZ ALEXANDER; KALID ORI; MARANTZ YAEL; NUDELMAN RAPHAEL; SBACHAM SHARON; BAR-HAIM SHAY
摘要:The invention discloses tachykinin receptor antagonists. The tachykinin family of receptors comprising the neurokinins substance P (SP), neurokinin A, and neurokinin B and related neuropeptides that are widely distributed in the peripheral and central nervous system. The invention discloses novel aminopyrimidine derivatives, synthesis and uses thereof for the treatment of diseases mediated directly or indirectly by the tachykinin receptors. These diseases include central nervous system disorders such as anxiety, pain, depression, emesis, in particular cancer chemotherapy induced emesis, respiratory and inflammatory bowel disease and other gastric disorders, asthma, schizophrenia, ophthalmic diseases such as glaucoma, ocular hypotension, neural injury, stroke, cardiac disorders, psoriasis, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-7030240-B2
优先权日:2003-03-31
标 题:Piperidinylamino-thieno[2,3-d] pyrimidine compounds
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; REDDY SEKAR A; CHERUKU SRINIVASA RAO; MELE NDEZ ROSA E; SHARADENDU ANURAG; CHEN DONGLI; MARANTZ YAEL; SHACHEM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; KESAVAN VENKITASAMY; BAR-HAIM SHAY
权利人:PREDIX PHARMACEUTICALS HOLDING
摘要:The invention relates to 5-HT receptor antagonists. Novel piperidinylamino-thieno[2,3-d] pyrimidine compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as anxiety, depression, schizophrenia, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.