CAS: 86-99-7; 7-Chloroquinolin-4-Ol

该化合物是属于奎诺派衍生物类别的有机化合物,在奎诺林环系4位置的7位置和4位置上有一个氯替代组和氢氧基化合物,该化合物的特点是黄色黄色至褐色颜色,在室温下一般是固体的,以其潜在的生物活动闻名,包括抗微生物和抗疟特性,使其对医药化学感兴趣,氢氧基化合物的存在有助于其溶解于极溶溶剂,而氯组可影响其再活性和与生物目标的相互作用. 7-Crolonoquinol可以参与各种化学反应,包括核分裂替代和金属离子的复杂.其结构特征使其能够充当开发新药品的宝座,特别是寻求有效治疗传染病.应当参考安全数据,以便处理和使用任何化学物质.

英文名称7-Chloroquinolin-4-Ol
中文名称7-氯-4-羟基喹啉
IUPAC名称7-chloroquinolin-4-ol
其它别名7-Chloro-4(1H)-Quinolinone; 7-Chloroquinolin-4(1H)-One; Unii-23Fwh4Ch0U; Nsc38
CAS编号86-99-7
MFCD编号:MFCD00006778
EINECS号:201-715-2
分子式:C9H6ClNO分子量:179.6
产品CID: 1874374
产品分类医药中间体 → 喹啉类化合物

相似结构搜索
产品信息参考;;
InChIKey: XMFXTXKSWIDMER-UHFFFAOYSA-N
InChI=1S/C9H6ClNO/c10-6-1-2-7-8(5-6)11-4-3-9(7)12/h1-5H,(H,11,12)
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
危险品标志Xi
安全声明26-37/39
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 7-Chloroquinolin-4-Ol 主要起始原料 7-Chloro-4-Hydroxy Quinoline-3-Carboxylic Acid
675578-65-1 = 86-99-7
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; Overnight,Reflux1.2 Reagents: Water
标题:A Novel Synthesis Of Substituted Quinolines Using Ring-Closing Metathesis (Rcm): Its Application To The Synthesis Of Key Intermediates For Anti-Malarial Agents
作者:Theeraladanon,Chumpol; Et Al
参考文献:Tetrahedron 日期:2004 卷标:60(13) 页码:3017-3035]

86-98-6 = 86-99-7
反应条件:1.1 Reagents: Acetic Acid; 1 H,125 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Rt1.3 Reagents: Acetic Acid; Acidified,Rt
标题:Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines And Tetraoxanes Potential Two-Stage Antimalarials?
作者:Terzic,Natasa; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2016 卷标:59(1) 页码:264-281]

26707-52-8 = 86-99-7
反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Water; 4 H,105 °C; 105 °C -> Rt1.2 Reagents: Water
标题:Efficient Method For Demethylation Of Aryl Methyl Ether Using Aliquat-336
作者:Waghmode,Suresh B.; Et Al
参考文献:Synthetic Communications 日期:2013 卷标:43(24) 页码:3272-3280]

408315-05-9 = 86-99-7
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water
标题:Cleavage Of Organic Sulfides With Chlorine
作者:Baker,Robert H.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1946 卷标:68 页码:2636-9]

3412-99-5 = 86-99-7
反应条件:1.1 4 H,240 °C; 240 °C -> Rt1.2 Solvents: Hexane; 15 Min,Rt
标题:Design,Synthesis And Study Of Antibacterial And Antitubercular Activity Of Quinoline Hydrazone Hybrids
作者:Shruthi,T. G.; Et Al
参考文献:Heterocyclic Communications 日期:2020 卷标:26(1) 页码:137-147]

21617-15-2 = 86-99-7 [标题:Reaction Conditions
标题:4-Hydroxyquinolines
参考文献:European Patent Organization]

108-59-8 = 86-99-7
反应条件:1.1 Catalysts: Magnesium,Ammonium Chloride2.1 -2.2 Reagents: Sodium Hydroxide Solvents: Water
标题:Process For Producing Isomer-Free 7-Chloro-4-Hydroxyquinoline
参考文献:Hungary]

= 86-99-7
反应条件:1.1 Catalysts: Grubbs Second Generation Catalyst Solvents: Dichloromethane; 1 H,50 °C2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; Overnight,Reflux2.2 Reagents: Water
标题:A Novel Synthesis Of Substituted Quinolines Using Ring-Closing Metathesis (Rcm): Its Application To The Synthesis Of Key Intermediates For Anti-Malarial Agents
作者:Theeraladanon,Chumpol; Et Al
参考文献:Tetrahedron 日期:2004 卷标:60(13) 页码:3017-3035]

86-98-6 = 86-99-7
反应条件:1.1 Reagents: Acetic Acid
标题:Reaction Of 4,7-Dichloroquinoline With Acetic Acid
作者:Cutler,Royal A.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1950 卷标:72 页码:3394-5]

86-98-6 = 86-99-7
反应条件:1.1 Reagents: Hydrochloric Acid,Water
标题:Displacement Of Nuclear Hydroxyl In Quinoline Series By Aryl-S Group
作者:Illuminati,G.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1950 卷标:72 页码:4288-9]

3412-99-5 = 86-99-7
反应条件:1.1 Reagents: Hexane Solvents: 1,1′-Biphenyl,Mixt. With 1,1′-Oxybis[benzene]; 15 Min,Rt
标题:Synthesis,Antituberculosis Studies And Biological Evaluation Of New Quinoline Derivatives Carrying 1,2,4-Oxadiazole Moiety
作者:Shruthi,T. G.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(1) 页码:97-102]

2033-24-1 = 86-99-7
反应条件:1.1 Reagents: Trimethyl Orthoformate; 1 H,Reflux; Cooled1.2 Solvents: Dimethylformamide; 2 H,Reflux; Reflux -> Rt1.3 Solvents: Water; Rt1.4 Solvents: Diphenyl Ether; 5 Min,Rt -> 300 °C; 300 °C -> Rt
标题:Synthesis Of Ring-Substituted 4-Aminoquinolines And Evaluation Of Their Antimalarial Activities
作者:Madrid,Peter B.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2005 卷标:15(4) 页码:1015-1018]

140646-24-8 = 86-99-7
反应条件:1.1 -1.2 Reagents: Sodium Hydroxide Solvents: Water
标题:Process For Producing Isomer-Free 7-Chloro-4-Hydroxyquinoline
参考文献:Hungary]

16600-22-9 = 86-99-7 [标题:Reaction Conditions
标题:Synthesis And Antitumor Activity Of Halogen-Substituted 4-(3,3-Dimethyl-1-Triazeno)Quinolines
作者:Lin,Ai Jeng; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:1978 卷标:21(3) 页码:268-72]

87-13-8 = 86-99-7
反应条件:1.1 4 H,110 °C; 110 °C -> Rt1.2 Solvents: Hexane; 15 Min,Rt2.1 4 H,240 °C; 240 °C -> Rt2.2 Solvents: Hexane; 15 Min,Rt
标题:Design,Synthesis And Study Of Antibacterial And Antitubercular Activity Of Quinoline Hydrazone Hybrids
作者:Shruthi,T. G.; Et Al
参考文献:Heterocyclic Communications 日期:2020 卷标:26(1) 页码:137-147]

87-13-8 = 86-99-7
反应条件:1.1 Solvents: Diethyl (Ethoxymethylene)Malonate; 4 H,110 °C2.1 Reagents: Hexane Solvents: 1,1′-Biphenyl,Mixt. With 1,1′-Oxybis[benzene]; 15 Min,Rt
标题:Synthesis,Antituberculosis Studies And Biological Evaluation Of New Quinoline Derivatives Carrying 1,2,4-Oxadiazole Moiety
作者:Shruthi,T. G.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(1) 页码:97-102]

18162-48-6 + 675578-63-9 = 86-99-7
反应条件:1.1 Reagents: Triethylamine,Sodium Iodide Solvents: Acetonitrile; 1 H,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water2.1 Catalysts: Grubbs Second Generation Catalyst Solvents: Dichloromethane; 1 H,50 °C3.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; Overnight,Reflux3.2 Reagents: Water
标题:A Novel Synthesis Of Substituted Quinolines Using Ring-Closing Metathesis (Rcm): Its Application To The Synthesis Of Key Intermediates For Anti-Malarial Agents
作者:Theeraladanon,Chumpol; Et Al
参考文献:Tetrahedron 日期:2004 卷标:60(13) 页码:3017-3035

📜7-氯-4-羟基喹啉-3-羧酸以二苯醚作为反应溶剂,化学反应 1.0H,反应生成 7-氯-4-羟基喹啉
参考文献:抗疟药:合成4-氨基喹啉类药物,可在疟疾寄生虫中规避耐药性†
标题:抗疟药:合成4-氨基喹啉类药物,可在疟疾寄生虫中规避耐药性†
摘要:此处描述的策略已允许合成一系列4-氨基喹啉抗疟药.对先前合成方法的实质性改进包括用纯胺而不是苯酚进行亲核取代,区域选择性还原烷基化以将二氨基烷烃侧链上的末端伯胺(12A-20A)转化为二乙氨基,以及通过使用碱性氧化铝的柱色谱法进行纯化.用硼氘化钠(与硼氢化钠相比)进行区域选择性还原烷基化后获得的1 H NMR光谱表明,该还原烷基化是通过形成并随后原位还原相应的二酰胺而进行的.
DOI:10.1002/jhet.5570340149