CAS: 84485-00-7; Sibutramine Hydrochloride

1-(1-四氯苯基)-3-甲基-1-丁胺置于盐酸,聚合甲醛,甲酸体系中,用 水 作为反应溶剂,化学反应生成 盐酸西布曲明
参考文献:A Study And Identification Of Potential By-Products Of Sibutramine
标题:A Study And Identification Of Potential By-Products Of Sibutramine
摘要:In The Synthesis And Process Development Of Sibutramine (9),The Isolation And Characterization Of Two Potential By-Products Namely Heptane Dinitriles (4A-B) And Bis-Cyclobutyl Alkylamine (10) Have Been Studied,The Key Steps In The Synthesis Of Sibutramine Which Have Contributed To The Formation Of Above By-Products Are Cycloalkylation Of 4-Chlorophenyl Acetonitrile (1) And Tandem Grignard Reduction On 1-(4-Chlorophenyl) Cyclobutyl Carbonitrile (3).
DOI:10.1021/op980093T

专利信息

专利号:US-8378072-B2
优先权日:2006-04-13
标题 :Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
发明人：BONNIN DUSTAN
权利人:DECLION PHARMACEUTICALS INC; BONNIN DUSTAN
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the modulation of unwanted immune responses, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use.

专利号:WO-2004058727-A1
优先权日:2002-12-20
标题 :Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
发明人：CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA
权利人:BAYER PHARMACEUTICALS CORP; CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA
摘要:This invention relates to substituted 3,5-dihydro-4H-imidazol-4-ones compounds which are useful in the treatment of obesity and obesity-related disorders, and as weight-loss and weight-control agents. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:JP-2011518154-A
优先权日:2008-04-16
标 题:A useful process for the synthesis of (R) -1- {2- [4 '-(3-methoxypropane-1-sulfonyl) -biphenyl-4-yl] -ethyl} -2-methyl-pyrrolidine

专利号:CN-102066319-A
优先权日:2008-04-16
标 题 :Processes useful for the synthesis of (R)-1-{2-[4'-(3-methoxypropane-1-sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine

专利号:EP-2282992-A1
优先权日:2008-04-16
标 题 :Processes useful for the synthesis of (r)-1-{2-ý4'-(3-methoxypropane-1-sulfonyl)-biphenyl-4-yl¨-ethyl}-2-methyl-pyrrolidine

专利号:CA-2719373-A1
优先权日:2008-04-16
标题:Processes useful for the synthesis of (r)-1-{2-[4'-(3-methoxypropane-1-sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine