CAS: 84392-17-6; 4'-(Trifluoromethyl)-[1,1'-Biphenyl]-2-Carboxylic Acid

该化合物是一种有机化合物,其特点是其双联苯结构被三氟甲基组和一个碳酸功能组所取代,该化合物通常具有芳烃化合物和箱状酸的特性,例如由于分子间相互作用很强,熔点和沸点相对较高;三氟甲基组的存在增强了其脂性,能够影响其再活性和生物活动;此外,箱状酸组有助于其酸性和氢联结潜力,这可能影响到各种溶剂中的溶性;该化合物可能因其独特的电子特性以及合成和催化中的潜在应用而对制药,农用化学品和材料科学等领域具有兴趣;其稳定性和再活性可能受到三氟甲基组的电子效应的影响,使其成为进一步研究和开发的宝贵化合物.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报REACH预注册

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4,4-dimethyl-2-(4'-trifluoromethyl-2-biphenyl)-2-oxazoline 4'-Trifluoromethyl-2-biphenylcarbaldehyde methyl 4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxylate p-trifluoromethylphenyl bromide 2,4'-diaminobiphenyl 4′-(trifluoromethyl)-[1,1′-biphenyl]-2-amine 5[H]phenanthridin-6-one carboxylic acid ethyl 1-methyl-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]-1H-indole-2-carboxylate

合成工艺路线路线简述

  • 84392-18-7 = 84392-17-6
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water1.2 Reagents: Sodium Hydroxide Solvents: Methanol,Water1.3 Reagents: Hydrochloric Acid Solvents: Water
    标题:The Nickel(I) Catalyzed Coupling Of A Diarylzinc With An Aryl Chloride In The Synthesis Of Xenalipin
    作者:Eaddy,John F.
    参考文献:Organic Preparations And Procedures International 日期:1995 卷标:27(3) 页码:367-72]

    167021-49-0 = 84392-17-6
    反应条件:1.1 Reagents: Oxygen Catalysts: Hydrochloric Acid,6-Bromobenzothiazole Solvents: Acetonitrile,Water; 24 H,60 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water
    标题:Light-Promoted Chlorine-Radical-Mediated Oxidation Of Benzylic C(Sp3)-H Bonds Utilizing Air As Oxidant
    作者:Xu,Ning; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2023 卷标:365(2) 页码:142-147]

    19312-06-2 + 455-13-0 = 84392-17-6
    反应条件:1.1 Reagents: Butyllithium,Zinc Chloride Solvents: Tetrahydrofuran1.2 Catalysts: Iodo[4-(Trifluoromethyl)Phenyl]Bis(Triphenylphosphine)Palladium Solvents: Tetrahydrofuran1.3 Reagents: Water Solvents: Diethyl Ether1.4 Reagents: Hydrochloric Acid1.5 Reagents: Sodium Hydroxide
    标题:Synthesis Of Carbon-14 Labeled Xenalipin,A Potential Hypolipidemic Agent
    作者:Hill,John A.; Et Al
    参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1992 卷标:31(12) 页码:1011-17]

    100-52-7 + 128796-39-4 = 84392-17-6
    反应条件:1.1 Reagents: Trifluoroacetic Acid,3-Aminobenzoic Acid,Quinone Catalysts: Palladium Diacetate Solvents: 1,4-Dioxane; 48 H,90 °C2.1 -
    标题:Suzuki-Miyaura Type Regioselective C-H Arylation Of Aromatic Aldehydes By A Transient Directing Strategy
    作者:Chao,Bao; Et Al
    参考文献:Organic Letters 日期:2023 卷标:25(37) 页码:6823-6829]

    124-68-5 + 98-88-4 = 84392-17-6
    反应条件:1.1 Solvents: Dichloromethane1.2 Reagents: Thionyl Chloride1.3 Reagents: Sodium Hydroxide Solvents: Water2.1 Reagents: Butyllithium,Zinc Chloride Solvents: Tetrahydrofuran2.2 Catalysts: Iodo[4-(Trifluoromethyl)Phenyl]Bis(Triphenylphosphine)Palladium Solvents: Tetrahydrofuran2.3 Reagents: Water Solvents: Diethyl Ether2.4 Reagents: Hydrochloric Acid2.5 Reagents: Sodium Hydroxide
    标题:Synthesis Of Carbon-14 Labeled Xenalipin,A Potential Hypolipidemic Agent
    作者:Hill,John A.; Et Al
    参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1992 卷标:31(12) 页码:1011-17]

    91748-18-4 = 84392-17-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 14 H,50 °C1.2 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate,Water; Rt
    标题:Vitamin Catalysis: Direct,Photocatalytic Synthesis Of Benzocoumarins Via (-)-Riboflavin-Mediated Electron Transfer
    作者:Morack,Tobias; Et Al
    参考文献:Organic Letters 日期:2018 卷标:20(5) 页码:1316-1319]

    91748-18-4 = 84392-17-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol; 5 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:Electronic Effects On The Substitution Reactions Of Benzhydrols And Fluorenyl Alcohols. Determination Of Mechanism And Effects Of Antiaromaticity
    作者:George,Stephen R. D.; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2015 卷标:13(43) 页码:10745-10750]

    84392-23-4 = 84392-17-6
    反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone,Water
    标题:Suzuki Cross-Coupling Of Arylboronic Acids Mediated By A Hydrosoluble Pd(0)/tppts Catalyst
    作者:Dupuis,C.; Et Al
    参考文献:Tetrahedron Letters 日期:2001 卷标:42(37) 页码:6523-6526]

    88-67-5 + 128796-39-4 = 84392-17-6
    反应条件:1.1 Catalysts: Palladium Diacetate Solvents: Water; 5 Min,Rt1.2 Reagents: Potassium Hydroxide; 1 H,Rt -> 75 °C; 4 H,75 °C
    标题:An Improved Protocol For Ligandless Suzuki-Miyaura Coupling In Water
    作者:Korolev,Dmitrii N.; Et Al
    参考文献:Tetrahedron Letters 日期:2006 卷标:47(25) 页码:4225-4229]

    610-97-9 + 128796-39-4 = 84392-17-6
    反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Palladium Diacetate Solvents: Acetonitrile,Water; Rt -> 60 °C; Overnight,60 °C1.2 Reagents: Sodium Hydroxide Solvents: Methanol,Water; Rt -> 50 °C; Overnight,50 °C
    标题:Transition-Metal-Free Synthesis Of Phenanthridinones Through Visible-Light-Driven Oxidative C-H Amidation
    作者:Usami,Kaoru; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2020 卷标:2020(10) 页码:1496-1504]

    610-97-9 + 128796-39-4 = 84392-17-6
    反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: Tetrahydrofuran,Water; 2 Min,Rt1.2 Rt; 12 H,80 °C1.3 Reagents: Sodium Hydroxide Solvents: Methanol,Water; Rt -> 50 °C; 12 H,50 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; < Ph 3
    标题:Photocatalytic Dehydrogenative Lactonization Of 2-Arylbenzoic Acids
    作者:Ramirez,Nieves P.; Et Al
    参考文献:Organic Letters 日期:2015 卷标:17(18) 页码:4550-4553]

    610-97-9 + 128796-39-4 = 84392-17-6 [标题:Reaction Conditions
    标题:Unveiling The Potency Of A Phenalenyl-Based Photocatalyst For Intramolecular Dehydrogenative Lactonization
    作者:Sen,Partha Pratim; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2024 卷标:11(1) 页码:106-112]

    65-85-0 + 402-51-7 = 84392-17-6
    反应条件:1.1 Reagents: N,N,N′,N′-Tetramethylethylenediamine,Sec-Butyllithium1.2 Reagents: Titanium Ethoxide Solvents: Tetrahydrofuran; Rt; 1 H,Rt -> 0 °C1.3 0.5 H,Rt1.4 Reagents: Oxygen Catalysts: 1,3-Dimethyl-3,4,5,6-Tetrahydro-2(1H)-Pyrimidinone,Cobalt Chloride (Cocl2) Solvents: Tetrahydrofuran; 10 H,Rt1.5 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Room-Temperature Cobalt-Catalyzed Arylation Of Aromatic Acids: Overriding The Ortho-Selectivity Via The Oxidative Assembly Of Carboxylate And Aryl Titanate Reagents Using Oxygen
    作者:Liu,Kun-Ming; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2016 卷标:14(5) 页码:1593-1598]

    149105-19-1 + 402-43-7 = 84392-17-6
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Acetonitrile,Water
    标题:A Practical Preparation Of 2-Carboxyphenylboronic Acid And Its Application For The Preparation Of Biaryl-2-Carboxylic Acids Using Suzuki Coupling Reactions
    作者:Tao,Bin; Et Al
    参考文献:Synthesis 日期:2002 卷标:(8) 页码:1043-1046]

    610-94-6 + 128796-39-4 = 84392-17-6
    反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Palladium Diacetate,2-Dicyclohexylphosphino-2′,6′-Dimethoxybiphenyl Solvents: Acetonitrile,Water; Overnight,Reflux2.1 Reagents: Sodium Hydroxide Solvents: Ethanol; 5 H,Reflux2.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:Electronic Effects On The Substitution Reactions Of Benzhydrols And Fluorenyl Alcohols. Determination Of Mechanism And Effects Of Antiaromaticity
    作者:George,Stephen R. D.; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2015 卷标:13(43) 页码:10745-10750
Isopropyl 4'-Trifluoromethylbiphenyl-2-Carboxylate置于potassium Hydroxide,盐酸体系中,用 N-甲基吡咯烷酮,水 作为反应溶剂,化学反应 3.0H,以72%的收率获得产物4-三氟甲基-联苯-2-甲酸
参考文献:Process For The Preparation Of 4`-Haloalkylbiphenyl-2-Carboxylic Acids
标题:Process For The Preparation Of 4`-Haloalkylbiphenyl-2-Carboxylic Acids
摘要:这项发明涉及一种制备可选择取代的4'-卤代烷基联苯-2-羧酸酯的方法,以及一种制备相应的可选择取代的4'-卤代烷基联苯-2-羧酸的方法.

海关参考信息

专利信息


专利号:EP-1607389-A1
优先权日:1999-09-10
标题:4-protected-amino-2-substituted-1,2,3,4-tetrahydroquinolines as intermediates for CETP inhibitors
发明人：DENINNO MICHAEL PAUL; MAGNUS-ARYITEY GEORGE TETTEH; RUGGERI ROGER BENJAMIN; WESTER RONALD THURE
权利人:PFIZER PROD INC
摘要:The present invention relates to compounds of formulan nwherein P 2 , R 2 , R 5 , R 6 , R 7 and R 8 are as defined herein, which are useful as intermediates innthe synthesis of 4-carboxyarnino-2-substitated-1,2,3,4-tetrahydroquinolines.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-4578522-A
优先权日:1983-08-31
标题:Biaryl aldehyde
发明人：EADDY III JOHN F
权利人:EADDY III JOHN F
摘要:This invention relates to a method of synthesis of certain substituted carboxylic acids useful in lowering serum triglyceride and total cholesterol levels in mammals (including man) represented by the general formula I: Ar1-Ar2 (I) wherein Ar1 is selected from Ar2 is selected from and R is selected from C1-5alkyl, halogen, perhalo-C1-4alkyl, C1-4alkoxy, phenyl, C1-4acyl, C1-6alkoxycarbonyl, amino or hydroxy.

专利号:CN-110862368-B
优先权日:2019-11-25
标 题 :A kind of photocatalytic oxidation synthesis method of benzocoumarins

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:CN-110862368-A
优先权日:2019-11-25
标题:A kind of photocatalytic oxidation synthesis method of benzocoumarins

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主要参考文献


1: Lewis MC, Hodgson GL, Shumaker TK, Namm DH. Evaluation of the hypolipidemic activity of xenalipin in experimental animals. Atherosclerosis. 1987 Mar;64(1):27-35. doi: 10.1039/c5ob02496j.

合成参考文献


摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 388.
摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 365.
摘要:Selt, M.; Waldvogel, S. R., Science of Synthesis: Special Topics, (2021) 1, 282.
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