专利号:US-10323010-B2 优先权日:2015-07-20 标题 :Methods of chemical synthesis of substituted 10H-phenothiazine-3,7-diamine compounds 发明人:STOREY JOHN MERVYN DAVID; LARCH CHRISTOPHER PAUL; KEMP STEVEN JOHN; CLUNAS SCOTT; NICOLL SARAH LOUISE; GIBBARD HELEN SARAH; SIMPSON MICHAEL; SINCLAIR JAMES PETER; MARSHALL COLIN 权利人:WISTA LAB LTD 摘要:The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.
专利号:US-12006540-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J 权利人:UNIV COLUMBIA 摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
专利号:US-9469542-B2 优先权日:2014-06-06 标 题:Large scale production of thinned graphite, graphene, and graphite-graphene composites 发明人:BOZALINA MARIE; PERRET PHILIPPE; NAZARPOUR SOROUSH 权利人:GROUP NANOXPLORE INC 摘要:Embodiments described herein relate generally to large scale synthesis of thinned graphite and in particular, few layers of graphene sheets and graphene-graphite composites. In some embodiments, a method for producing thinned crystalline graphite from precursor crystalline graphite using wet ball milling processes is a disclosed herein. The method includes transferring crystalline graphite into a ball milling vessel that includes a grinding media. A first and a second solvent are transferred into the ball milling vessel and the ball milling vessel is rotated to cause the shearing of layers of the crystalline graphite to produce thinned crystalline graphite.
专利号:US-11959137-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
专利号:US-2024376536-A1 优先权日:2015-09-28 标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis
专利号:US-2022411860-A1 优先权日:2015-09-28 标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis