CAS: 78338-22-4; 3,7-Diaminophenothiazin-5-Ium Acetate

该化合物是一种合成的硫酸染料,通常用于生物污渍和生理学.它作为核酸的代谢性污渍,特别是在细胞结构中识别DNA和RNA.该化合物显示出酸组织成分的强烈亲近性,使其在显微镜和诊断应用中具有价值.它的红氧化特性也能够用于电化学研究.Thionin 乙酸盐在水和乙醇中溶解,确保符合标准实验室协议.染料的稳定性和持续污渍性能使研究人员在组织病理学,细胞学和物质科学方面做出可靠的选择.建议正确处理和储存以保持其功效.

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leucothionine7-Imino-7H-phenothiazin-3-ylamine

合成工艺路线路线简述

  • 合成目标产物 Ci 52000 主要起始原料 10H-Phenothiazine-3,7-Diamine
  • (文献来源)合成步骤主要原料 10H-Phenothiazine-3,7-Diamine
📜Leucothionine置于氧气体系中,用 水 作为反应溶剂,20.0 °C,100.0 Kpa 条件下,反应生成 硫堇(劳氏紫)
参考文献:氢化/氧化引发有机分子的高效可逆颜色转换†
标题:氢化/氧化引发有机分子的高效可逆颜色转换†
摘要:催化加氢和氧化脱氢反应是有机转化的基础和重要过程,有机氧化还原染料的可逆颜色转换在可重写纸,传感设备,数据记录和安全特征技术中具有潜在的应用.在这项研究中,我们报告了在环境条件下,Pd-Zno 1-X杂化纳米催化剂上氧化还原染料可逆氢化和氧化脱氢的有趣结果.硫氨酸(th +)用作模型化合物,以评估催化性能.紫色硫氨酸(th +)和无色隐硫硫氨酸(lth)之间可逆的颜色切换取决于还原或氧化环境.我们新开发的pd-zno 1−x纳米催化剂在h 2(1 Bar)下具有高达397 H-1的周转频率(tof),显示出对th +氢化的高催化活性.在相同的反应系统中,Lth的氧化脱氢在1 Bar O 2流量下进行.pd-zno 1-X纳米催化剂易于吸附并随后离解o 2,从而以较高的效率将lth氧化为原始的紫色th +.zno 1-X上的大量氧空位纳米棒和强大的金属-载体相互作用(smsi)促
DOI:10.1039/c6Cy02585D

海关参考信息

专利信息


专利号:US-10323010-B2
优先权日:2015-07-20
标题 :Methods of chemical synthesis of substituted 10H-phenothiazine-3,7-diamine compounds
发明人:STOREY JOHN MERVYN DAVID; LARCH CHRISTOPHER PAUL; KEMP STEVEN JOHN; CLUNAS SCOTT; NICOLL SARAH LOUISE; GIBBARD HELEN SARAH; SIMPSON MICHAEL; SINCLAIR JAMES PETER; MARSHALL COLIN
权利人:WISTA LAB LTD
摘要:The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-9469542-B2
优先权日:2014-06-06
标 题:Large scale production of thinned graphite, graphene, and graphite-graphene composites
发明人:BOZALINA MARIE; PERRET PHILIPPE; NAZARPOUR SOROUSH
权利人:GROUP NANOXPLORE INC
摘要:Embodiments described herein relate generally to large scale synthesis of thinned graphite and in particular, few layers of graphene sheets and graphene-graphite composites. In some embodiments, a method for producing thinned crystalline graphite from precursor crystalline graphite using wet ball milling processes is a disclosed herein. The method includes transferring crystalline graphite into a ball milling vessel that includes a grinding media. A first and a second solvent are transferred into the ball milling vessel and the ball milling vessel is rotated to cause the shearing of layers of the crystalline graphite to produce thinned crystalline graphite.

专利号:US-11959137-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-2024376536-A1
优先权日:2015-09-28
标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2022411860-A1
优先权日:2015-09-28
标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

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合成参考文献


摘要:Hartung, J.; Heydt, H., Science of Synthesis, (2009) 38, 125.
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