CAS: 7752-78-5; 5-Bromo-2-Methylpyrimidine

相似化合物

1135283-08-7 38275-57-9 1193116-74-3

上下游产品

CAS号100707-39-9 5-溴-2-甲基嘧啶-4-甲酸 | CAS号75-24-1 三甲基铝 | CAS号183438-24-6 5-溴-2-碘嘧啶 | CAS号544-97-8 二甲基锌 | CAS号114078-88-5 5-溴-1,2,3-三嗪 | CAS号143-37-3 acetamidine | CAS号35231-56-2 2-甲基-5-羟基嘧啶 | CAS号83410-38-2 5-溴-2-甲基嘧啶-4-甲酸乙酯 | CAS号5194-32-1 2-甲基-5-嘧啶甲酸 | CAS号1225223-42-6 1-(2-甲基-5-嘧啶基)乙酮

2-甲基-5-溴嘧啶-4-羧酸 以 5,5-Dimethyl-1,3-Cyclohexadiene 作为反应溶剂,化学反应 2.0H,以61%的收率获得产物2-甲基-5-溴嘧啶
参考文献:亜鉛結合部分を有するホスホイノシチド3−キナーゼインヒビター
标题:亜鉛結合部分を有するホスホイノシチド3−キナーゼインヒビター
摘要:要解决的问题:提供具有锌结合基团的磷脂酰肌醇3-激酶抑制剂.解决方案:提供了一个由下图中的式(i)表示的化合物.(x为s,O或类似物;y为ch,N或类似物;g是可选地取代的n或类似物;r和r分别独立地为h或类似物;c为取代的杂环或类似物;b为线性烷基或类似物;r和r与它们结合的氮原子一起是吗啡基或类似物;g是吲唑环或类似物;q,R和s独立地从0到1,但至少其中之一为1;t从0到1;n从0到4;p从0到2.)

专利信息

专利号:US-6121448-A
优先权日:1995-03-28
标题 :Pyrimidine compounds
发明人：LEWIS ROBERT ANDREWS; GOODBY JOHN WILLIAM; TOYNE KENNETH JOHNSON; HIRD MICHAEL
权利人:SECR DEFENCE BRIT
摘要:The synthesis of novel compound (I) is described: 5-bromo-2-iodopyrimidine may be used for the synthesis of a range of chemical compounds both known and novel. The synthesis of a number of novel liquid crystalline compounds is described.

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ• CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:WO-2024185814-A1
优先权日:2023-03-06
标题:Method for producing aryl compound containing tritylsulfanyl group
发明人：OKAZOE TAKASHI; NOZAKI KYOKO; GATZENMEIER Tim; LIU YUE
权利人:AGC INC; UNIV TOKYO
摘要:The present invention provides: a substrate for achieving the highly efficient synthesis of an aryl compound containing a tritylsulfanyl group; a method for producing a compound containing an SF 5 group using the substrate; and others. The present invention is a method for producing an aryl compound containing a tritylsulfanyl group, the method comprising thiotritylating a halogenated aryl compound represented by general formula (1) [wherein A 1 represents an aryl group that may have a substituent or a heteroaryl group that may have a substituent; and X represents a halogen atom] using [(triphenylmethyl)sulfanyl]potassium or [(triphenylmethyl)sulfanyl]sodium to produce an aryl compound containing a tritylsulfanyl group, the aryl compound being represented by general formula (2) [wherein A 1 is the same as A 1 in general formula (1); and Ph represents a phenyl group].

专利号:US-8785632-B2
优先权日:2004-08-26
标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE
权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER
摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:US-2006178374-A1
优先权日:2004-08-26
标 题 :Aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG J; FUNK LEE A; JIA LEI; KUNG PEI-PEI; MENG JERRY J; NAMBU MITCHELL D; PAIRISH MASON A; SHEN HONG; TRAN-DUBE MICHELLE
权利人:AGOURON PHARMA
摘要:Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:CN-106588783-B
优先权日:2017-02-16
标题 :A method of synthesis 2- trifluoromethyl -5- Bromopyrimidines