CAS: 7246-14-2; Methicillin Sodium (500 Mg) (As)
该化合物是一种属于青霉素类的半合成抗生素,主要用于治疗由生成软膜素的青蒿素酶酶造成的感染,其特征是能够抗受某些乙型林丹酶酶降解,使其对特定菌株有效.甲西林一般以其钠状施用,以提高溶性性和生物利用率.该物质是白的,非白的晶体素粉,在水中溶解,便于在临床环境中使用,其行动机制包括抑制细菌细胞壁合成,导致细胞分解和死亡.由于甲西林的抗甲西林抗甲状腺素出现,今天该物质并不常用,但该物质在抗生素抗药性研究中仍是一种重要的历史抗生素.适当的储存条件对于保持其稳定性至关重要,应当以实验室的谨慎处理.
- 英文名称Methicillin Sodium (500 Mg) (As)
- 中文名称甲氧苯青霉素
- IUPAC名称sodium (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
- 其它别名Methicillin sodium hydrate; Methicillin SodiuM (AS)
- CAS编号7246-14-2
- MFCD编号:MFCD07787409
- EINECS号:110-845-8
- 分子式:C17H19N2O6S.Na.H2O分子量:420.41261
- 产品CID: 1709486
- 同类组份化合物CAS61-32-5 (free base)7246-14-2 (sodium hydrate)132-92-3 (sodium)
- 产品分类原料药 → 抗生素类药物 → 青霉素类药
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
海关参考信息
- 2905121000-正丙醇
2905130000-正丁醇
2907221000-对苯二酚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:CN-115353539-B
优先权日:2022-07-13
标题 :Application of oligomeric nucleic acid-tetrahydrothiazole compounds in the synthesis of gene-encoded compound libraries
专利号:CN-115353539-A
优先权日:2022-07-13
标题:Application of oligomeric nucleic acid-tetrahydrothiazole compounds in the synthesis of gene-encoded compound libraries
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主要参考文献
1: Shrestha NK, Fraser TG, Gordon SM. Methicillin Resistance in Staphylococcus aureus Infections among Patients Colonized with Methicillin-Susceptible Staphylococcus aureus. Clin Microbiol Infect. 2018 Apr 9. pii: S1198-743X(18)30323-9. doi: 10.1016/j.cmi.2018.03.045. [Epub ahead of print] doi: 10.2174/1874434601812010036. eCollection 2018.
4: Wang X, Thompson CD, Weidenmaier C, Lee JC. Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform. Nat Commun. 2018 Apr 11;9(1):1379. doi: 10.1038/s41467-018-03847-z. pii: E119. doi: 10.3390/md16040119. doi: 10.3947/ic.2018.50.1.11. Review. doi: 10.1186/s13756-018-0340-2. eCollection 2018.
13: Mody L, Foxman B, Bradley S, McNamara S, Lansing B, Gibson K, Cassone M, Armbruster C, Mantey J, Min L. Longitudinal Assessment of Multidrug-Resistant Organisms in Newly Admitted Nursing Facility Patients: Implications for an Evolving Population. Clin Infect Dis. 2018 Apr 9. doi: 10.1093/cid/ciy194. [Epub ahead of print] doi: 10.1007/s40800-018-0080-5. doi: 10.1302/0301-620X.100B4.BJJ-2017-1080.R1.
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