CAS: 65412-03-5; 4-(2-Aminoethyl)Tetrahydro-2H-Pyran

相似化合物

389621-77-6 1314961-38-0 1083216-46-9

上下游产品

CAS号29943-42-8 四氢吡喃酮 | CAS号2537-48-6 氰甲基磷酸二乙酯 | CAS号40500-10-5 四氢-2H-吡喃-4-丙酸

📜4-氰基甲基四氢吡喃置于palladium On Activated Charcoal,氢气体系中,用 乙醇 作为反应溶剂,25.0 °C,1.0 Mpa 条件下,反应 12.0H,以76.1%的收率获得产物4-(2-氨乙基)四氢吡喃
参考文献:一种4-(2-氨乙基)四氢吡喃的合成方法
标题:一种4-(2-氨乙基)四氢吡喃的合成方法
摘要:本发明属于化学药物中间体的合成技术领域,具体涉及一种药物贝福普兰中间体4‑(2‑氨乙基)四氢吡喃的合成方法.该方法包括如下步骤:(1)4‑氯四氢吡喃与氰乙酸甲酯反应得到2‑氰基‑2‑(四氢‑4‑吡喃基)乙酸甲酯;(2)2‑氰基‑2‑(四氢‑4‑吡喃基)乙酸甲酯脱酯得到(四氢‑4‑吡喃基)‑乙腈;(3)(四氢‑4‑吡喃基)‑乙腈 C加氢反应得到4‑(2‑氨乙基)四氢吡喃.该方法采用4‑氯四氢吡喃,氰乙酸甲酯为原料,该方法反应时间短,成本较低,原料易得,无剧毒管制及不稳定的化学原料,安全有效,产率较高,杂质较少.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:EP-3103803-B1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:EP-3660020-A1
优先权日:2008-10-27
标题 :Process for the synthesis of mtor kinase inhibitors

专利号:EP-3103803-A1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:EP-3660020-B1
优先权日:2008-10-27
标题:Process for the synthesis of mtor kinase inhibitors