CAS: 6145-41-1; 1-(3-Chlorophenyl)Guanidine

该化合物是一种有机化合物,其特征是瓜尼丁结构,其特征是代之以代之以氯原子的苯基组,该化合物一般是白色至白色固态,以其在水和酒精等极溶剂中的溶解性而著称;氯原子的存在会增强其反应性,并可能影响其生物活动,使其在包括药用化学在内的各个领域中引起兴趣. 3-氯苯并呋喃已经研究过其在药理学中的潜在应用,特别是作为一种药理剂,可能与特定的受体或酶发生相互作用,其化学配方包括碳,氢,氮和氯,反映其各种功能组.

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CAS号420-04-2 氰胺 | CAS号108-42-9 间氯苯胺 | CAS号141-85-5 间氯苯胺盐酸盐

合成工艺路线路线简述

    📜氰胺,3-氯苯胺置于硝酸体系中,用 乙醇,水 作为反应溶剂,化学反应生成 3-氯苯基胍
    参考文献:Identification Of Pyrimidine Derivatives As Hsmg-1 Inhibitors
    标题:Identification Of Pyrimidine Derivatives As Hsmg-1 Inhibitors
    摘要:Hsmg-1 Kinase Plays A Dual Role In A Highly Conserved Rna Surveillance Pathway Termed Nonsense-Mediated Rna Decay (Nmd) And In Cellular Genotoxic Stress Response. Since Deregulation Of Cellular Responses To Stress Contributes To Tumor Growth And Resistance To Chemotherapy,Hsmg-1 Is A Potential Target For Cancer Treatment. From Our Screening Efforts,We Have Identified Pyrimidine Derivatives As Hsmg-1 Kinase Inhibitors. We Report Structure-Based Optimization Of This Pan-Kinase Scaffold To Improve Its Biochemical Profile And Overall Kinome Selectivity,Including Mtor And Cdk,To Generate The First Reported Selective Hsmg-1 Tool Compound. (C) 2012 Elsevier Ltd. All Rights Reserved.
    DOI:10.1016/j.Bmcl.2012.08.107

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    专利号:CN-107311937-A
    优先权日:2016-12-31
    标 题:A class of licochalcone A dihydroaminopyrimidine compounds with antitumor activity and its synthesis method

    专利号:CN-106674129-A
    优先权日:2016-12-31
    标题:A class of licochalcone A dihydroaminopyrimidine compounds with antitumor activity and its synthesis method

    专利号:CN-106380598-A
    优先权日:2016-10-15
    标 题 :A kind of synthesis method and application of polymer ionic liquid

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    合成参考文献


    参考文献:10.1016/j.ejphar.2005.10.037
    摘要:Dukat M, Wesołowska A. Antinociception: mechanistic studies on the action of MD-354 and clonidine. Part 1. The 5-HT3 component. Eur J Pharmacol. 2005 Dec 28;528(1-3):59–64. doi: 10.1016/j.ejphar.2005.10.037.
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