CAS: 6000-43-7; Glycine Hydrochloride

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7490-96-2 513-29-1 56-40-6

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CAS号56-40-6 甘氨酸 | CAS号70288-73-2 methoxycarbonyl... | CAS号1334715-68-2 cyclo-(Gly-cis-... | CAS号1068-90-2 乙酰氨基丙二酸二乙酯 | CAS号1185-53-1 三羟甲基氨基甲烷盐酸盐 | CAS号1186048-83-8 desm°Cyclopeptide | CAS号367-62-4 (2,2,2-三氟乙酰基氨基)-乙酸乙酯 | CAS号495-69-2 马尿酸 | CAS号15166-50-4 2-[(2,2,2-三氯乙酰基... | CAS号124-38-9 二氧化碳 | CAS号74-89-5 氨基甲烷 | CAS号39540-30-2 甘氨酸正辛酯盐酸盐 | CAS号459-73-4 2-胺基乙酸乙酯 | CAS号2185-00-4 甘氨酸-N-羧基-环内酸 | CAS号5680-79-5 甘氨酸甲酯盐酸盐 | CAS号590-02-3 氯乙酸丁酯 | CAS号13048-99-2 甘氨酸丁酯盐酸盐 | CAS号1032-44-6 2-(2,4,6-trinit... | CAS号1080-44-0 N-对甲苯磺酰甘氨酸

专利信息

专利号:US-12208146-B2
优先权日:2018-11-19
标 题 :Reconstituted HDL nanoparticles for delivery of radioactive agents and uses thereof
发明人：LACKO ANDRAS G; PROKAI LASZLO; ISAAC-OLIVÉ KEILA
权利人:UNIV OF NORTH TEXAS HEALTH SCIENCE CENTER; THE AUTONOMOUS UNIV OF THE STATE OF MEXICO
摘要:Despite the widespread use of nanotechnology in radio-imaging applications, lipoprotein based delivery systems received only limited attention so far. The subject application provides for the synthesis of a novel hydrophobic radio-imaging tracer. This tracer, comprising a hydrazinonicotinic acid (HYNIC)-N-dodecylamide and 99mTc conjugate can be encapsulated into rHDL nanoparticles (NPs). These rHDL NPs can selectively target the Scavenger Receptor type B1 (SR-B1) that is overexpressed on most cancer cells due to excess demand for cholesterol for membrane biogenesis and thus can target tumors in-vivo. Details of the tracer synthesis, characterization of rHDL/tracer complex, in-vitro uptake, stability studies and in-vivo application of this new radio-imaging approach are provided.

专利号:US-9676799-B2
优先权日:2012-07-17
标 题 :Method for the synthesis of N-(phosphonomethyl)glycine
发明人：BURCK SEBASTIAN; BRUYNEEL FREDERIC; NOTTE PATRICK
权利人:STRAITMARK HOLDING AG
摘要:A method for the synthesis of N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters, or its phosphonate ester salts, which includes the steps of: a) forming, in the presence an acid catalyst, a reaction mixture having 2,5-diketopiperazine, formaldehyde and a compound including one or more P-0-P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V), to form N,N′-bisphosphonomethyl-2,5-diketopiperazine, its mono- to tetra phosphonate esters, the dehydrated forms of N,N′-bisphosphonomethyl-2,5-diketopiperazine and the phosphonate esters of its dehydrated forms; and b) hydrolyzing the N,N′-bisphosphonomethyl-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters to obtain N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts.

专利号:US-8088740-B2
优先权日:2009-05-04
标题:Gold binding peptides and shape-and size-tunable synthesis of gold nanostructures
发明人：HUR HOR GIL; KIM JUNG OK; KIM DAE HEE; MYUNG NO SANG
权利人:HUR HOR GIL; KIM JUNG OK; KIM DAE HEE; MYUNG NO SANG; KWANGJU INST SCI & TECH
摘要:The present invention relates to gold binding peptides and shape- and size-tunable synthesis of gold nanostructures. The present inventions are very useful for the production of well-designed, gold-based architectures. The size- and shape-specific gold nanostructure materials prepared by the present invention may find use as: highly conductive interconnections for single-electron transistors, catalysts for the oxidation of carbon monoxide; biological and chemical sensors; and as contrasting agents for electron microscopic and medical imaging applications.

专利号:WO-0120995-A9
优先权日:1999-09-23
标题:Compounds directed against pilus biogenesis and activity in pathogenic bacteria; methods and compositions for synthesis thereof
发明人：KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY
权利人:UNIV WASHINGTON; KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY
摘要:Many Gram-negative pathogens assemble adhesive structures on their surfaces that allow them to colonize host tissues and cause disease. Novel compositions which inhibit or prevent the formation of a pilus chaperone-subunit complex are disclosed. Interfering with the function of the pili chaperone negatively affects the chaperone/usher pathway which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures and thus prevent or inhibit pilus assembly. Also provided are methods for the treatment or prevention of diseases caused by tissue-adhering pilus-forming bacteria by inhibiting the function of pilus chaperones. Also provided are pharmaceutical preparations capable of inhibiting or preventing the formation of a pilus chaperone-subunit complex. Also provided are methods of synthesizing the N-substituted amino acid compounds and compounds useful for the synthesis thereof. In particular, novel fluorinated linker compounds and methods of synthesis are provided. Methods for using the fluorinated linker compounds in methods of solid-phase synthesis of the N-substituted amino acid compounds are also disclosed.

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-2005186197-A1
优先权日:2002-08-29
标 题:Peptide inhibitors of beta lactamases
发明人：PALZKILL TIMOTHY; HUANG WANZHI
摘要:Peptide inhibitors of β-lactamases have been identified by the synthesis of peptide arrays using synthesis SPOT technology. These peptide inhibitors of β-lactamase have activity against a broad spectrum of β-lactamases and are useful in a variety of applications.