CAS: 578-86-9; (S)-7-Hydroxy-2-(4-Hydroxyphenyl)Chroman-4-One

该化合物是一种来自甘哲里沙物种(如甘醇)根部的氟虫素化合物,它具有一种铬结构,以其潜在的生物活动而闻名,包括抗氧化剂,抗炎和雌激素特性.作为植物质,利基里蒂琴因与雌激素受体相互作用,使其对荷尔蒙研究感兴趣.其低分子量和有利的生物利用率增强了其在药理学研究中的效用.该化合物还因其...

结构式图片

上下游产品

CAS号961-29-5 异甘草素; 4,2',4'-三羟基查耳酮 | CAS号551-15-5 甘草苷 | CAS号31524-62-6 异补骨脂黄酮 | CAS号7400-08-0 对羟基肉桂酸 | CAS号108-46-3 间苯二酚 | CAS号2196-14-7 7,4'-二羟基黄酮 | CAS号486-66-8 大豆苷元

合成工艺路线路线简述

    📜反式-4-甲氧基肉桂酸置于草酰氯,三溴化硼,柠檬酸体系中,用 二氯甲烷,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 50.0H,反应生成 甘草素
    参考文献:Tw2017/22896
    标题:Tw2017/22896

    海关参考信息

    专利信息


    专利号:US-7202398-B2
    优先权日:2002-08-16
    标 题 :Chalcone isomerase
    发明人:MCGONIGLE BRIAN
    权利人:DU PONT
    摘要:An isolated nucleic acid fragment encoding a chalcone isomerase is disclosed. Also of concern is the synthesis of a recombinant DNA construct encoding all or a portion of the chalcone isomerase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the chalcone isomerase in a transformed host cell.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:CN-114854703-B
    优先权日:2022-05-23
    标 题 :A kind of flavone synthase I/flavanone-3-hydroxylase and its application in the field of synthesis of flavonoids

    专利号:EP-1493431-B1
    优先权日:2003-07-03
    标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions
    发明人:WIRTH CORINNA DR; BUCHHOLZ HERWIG DR
    权利人:MERCK PATENT GMBH
    摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.

    专利号:CN-119331888-A
    优先权日:2024-10-10
    标题:Polygonatum cyrtonema PcF3H gene and application thereof in promotion of synthesis of dihydroflavonoid compounds and catalysis of naringenin hydroxylation

    专利号:CN-114891807-A
    优先权日:2022-05-30
    标 题:Application of CYP450 gene in regulation and control of synthesis of soybean isoflavone

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Min JK, Lee CH, Jang SE, Park JW, Lim SJ, Kim DH, Bae H, Kim HJ, Cha JM. Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin. J Gastroenterol Hepatol. 2015 May;30(5):858-65. doi: 10.1111/jgh.12812. doi: 10.1002/ptr.5071. Epub 2013 Oct 3. doi: 10.1039/c4fo00127c. doi: 10.1038/srep05676.
    5: Uchino K, Okamoto K, Sakai E, Yoneshima E, Iwatake M, Fukuma Y, Nishishita K, Tsukuba T. Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation. Phytother Res. 2015 Nov;29(11):1714-21. doi: 10.1002/ptr.5416. Epub 2015 Jul 14. doi: 10.1016/j.biopha.2016.11.009. Epub 2016 Nov 15. doi: 10.1016/j.psychres.2016.04.002. Epub 2016 Apr 14. doi: 10.1002/bmc.2787. Epub 2012 Jul 20.
    10: Tao W, Dong Y, Su Q, Wang H, Chen Y, Xue W, Chen C, Xia B, Duan J, Chen G. Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway. Behav Brain Res. 2016 Jul 15;308:177-86. doi: 10.1016/j.bbr.2016.04.039. Epub 2016 Apr 22. doi: 10.1155/2016/9178097. Epub 2016 May 26.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1021/bi0255266
    摘要:Jez JM, Bowman ME, Noel JP. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry. 2002 Apr 23;41(16):5168–76. doi: 10.1021/bi0255266.
    参考文献:10.1016/j.phytochem.2006.05.008
    摘要:Lee MH, Lin YP, Hsu FL, Zhan GR, Yen KY. Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. Phytochemistry. 2006 Jun;67(12):1262–70. doi: 10.1016/j.phytochem.2006.05.008.
    参考文献:10.1021/jf201280z
    摘要:Piccinelli AL, Lotti C, Campone L, Cuesta-Rubio O, Campo Fernandez M, Rastrelli L. Cuban and Brazilian red propolis: botanical origin and comparative analysis by high-performance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry. J Agric Food Chem. 2011 Jun 22;59(12):6484–91. doi: 10.1021/jf201280z.
    参考文献:10.1021/acs.jnatprod.6b00783
    摘要:Li K, Ji S, Song W, Kuang Y, Lin Y, Tang S, Cui Z, Qiao X, Yu S, Ye M. Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. J Nat Prod. 2017 Feb 24;80(2):334–46. doi: 10.1021/acs.jnatprod.6b00783.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知