CAS: 471843-75-1; (R)-4-(1-Aminoethyl)-N-(1H-Pyrrolo[2,3-B]Pyridin-4-yl)Benzamide Hydrochloride

英文名称(R)-4-(1-Aminoethyl)-N-(1H-Pyrrolo[2,3-B]Pyridin-4-yl)Benzamide Hydrochloride
中文名称(R)-4-(1-氨基乙基)-N-1H-吡咯并[2,3-B]吡啶-4-基苯甲酰胺盐酸盐
IUPAC名称Y-33075 hydrochloride
其它别名Benzamide, 4-((1R)-1-Aminoethyl)-N-1H-Pyrrolo(2,3-B)Pyridin-4-Yl-, Hydrochloride (1:1); 4-[(1R)-1-Aminoethyl]-N-(1H-Pyrrolo[2,3-B]Pyridin-4-yl)Benzamide; Hydrochloride; (R)-4-(1-
CAS编号471843-75-1
FDA UNII编号:3304VH0J6B
分子式:C16H17ClN4O分子量:316.79
产品CID: 1465800
同类组份化合物CAS173897-44-4 (2HCl)199433-58-4 (free base)471843-75-1 (HCl)
产品分类医药中间体 → 吡啶类化合物

相似结构搜索
InChIKey: IILQESWQPZIAGP-HNCPQSOCSA-N
InChI=1S/C16H16N4O.ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15;/h2-10H,17H2,1H3,(H2,18,19,20,21);1H/t10-;/m1./s1
计算化学: 氢键受体数3.0氢键供体数4.0可旋转键数3.0

MSDS等安全信息

上下游产品

(R)-(+)-4-(1-benzyloxycarbonylaminoethyl)-benzoic acid (R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride (R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide

合成工艺路线路线简述

📜(R)-(+)-4-(1-Benzyloxycarbonylaminoethyl)-Benzoic Acid置于盐酸,氯化亚砜,10% Palladium Hydroxide On Charcoal,氢气,N,N-二异丙基乙胺,Sodium Hydroxide体系中,用甲醇,乙醇,二氯甲烷,水,N,N-二甲基甲酰胺,乙腈作为反应溶剂,化学反应 15.0H,反应生成 (R)-4-(1-氨基乙基)-N-1H-吡咯并[2,3-B]吡啶-4-基苯甲酰胺盐酸盐
参考文献:Visual Function Disorder Improving Agents
标题:Visual Function Disorder Improving Agents

海关参考信息

2902600000-乙苯
2912110000-甲醛
2912210000-苯甲醛
2933310010-吡啶
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详情请参考：📖 海关编码查询和海关进出口税则

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✅ COA系统入驻 | 共享模式

主要参考文献

1: Catral KPC, Tse CY, Yang WY, Ling CY, Kwok OL, Choy KY, Lu DQ, Bian JF, Lam TC, Tse DY, Shan SS. Thrombospondin 1 Mediates Autophagy Upon Inhibition of the Rho-Associated Protein Kinase Inhibitor. Cells. 2024 Nov 18;13(22):1907. doi: 10.3390/cells13221907.
2: Du Y, Yang Z, Shi H, Chen Z, Chen R, Zhou F, Peng X, Hong T, Jiang L. E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA. Cell Death Dis. 2024 May 16;15(5):340. doi: 10.1038/s41419-024-06729-z.
3: Polopalli S, Saha A, Niri P, Kumar M, Das P, Kamboj DV, Chattopadhyay P. ROCK Inhibitors as an Alternative Therapy for Corneal Grafting: A Systematic Review. J Ocul Pharmacol Ther. 2023 Nov;39(9):585-599. doi: 10.1089/jop.2023.0040. Epub 2023 Sep 22.

合成参考文献

参考文献:10.3892/or.2012.2205
摘要:Yang Z, Wang J, Liu X, Cheng Y, Deng L, Zhong Y. Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Oncol Rep. 2013 Mar;29(3):1140–6. doi: 10.3892/or.2012.2205.
参考文献:10.1186/s13287-021-02611-3
摘要:Smeringaiova I, Utheim TP, Jirsova K. Ex vivo expansion and characterization of human corneal endothelium for transplantation: a review. Stem Cell Research & Therapy. 2021 Oct 30;12(1):554. doi: 10.1186/s13287-021-02611-3.