CAS: 42971-12-0; (+/-)-3-Epi-Apovincaminic Acid Ethyl Ester

该化合物是一种1型磷化酶(PDE1)抑制剂, 调节循环核素信号路径. (3R,16R)-苯丙胺正在研究其潜在应用于认知增强和脑血管紊乱方面, 因为它有能力加强大脑代谢和减少...

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    (10R,11R,11aS,11bR)-11a-Ethyl-11-hydroxy-2,3,4,5,10,11,11a,11b-°Ctahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid ethyl ester chloroacetic acid ethyl ester quinolizine-1-carbaldehyde(1R*,5S*,12bS*)-1-ethyl-1,2,3,4,6,7,12,12b-°Ctahydroindolo2,3-aquinolizine-1-carbaldehyde (10S,11S,11aS,11bR)-11a-Ethyl-11-hydroxy-2,3,4,5,10,11,11a,11b-°Ctahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid ethyl ester1S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolyl[3,2,1-de]pyridyl[3,2,1-ij][1,5]naphthyridine-12-yl)methanol((41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolyl[3,2,1-de]pyridyl[3,2,1-ij][1,5]naphthyridine-12-yl)methanol

    合成工艺路线路线简述

      📜Wenkert'S Enamine Perchlorate置于lead(Iv) Acetate,Sodium Tetrahydroborate,二乙基异丙基胺,Potassium Tert-Butylate,Potassium Carbonate体系中,用 甲醇,二氯甲烷,苯 作为反应溶剂,化学反应 28.33H,反应生成 长春西汀杂质 A
      参考文献:Danieli,Bruno; Lesma,Giordano; Palmisano,Giovanni,Gazzetta Chimica Italiana,1981,Vol. 111,# 7/8,P. 257-268
      标题:Danieli,Bruno; Lesma,Giordano; Palmisano,Giovanni,Gazzetta Chimica Italiana,1981,Vol. 111,# 7/8,P. 257-268

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      合成参考文献


      参考文献:10.1073/pnas.2005463117
      摘要:Abrams RPM, Yasgar A, Teramoto T, Lee MH, Dorjsuren D, Eastman RT, Malik N, Zakharov AV, Li W, Bachani M, Brimacombe K, Steiner JP, Hall MD, Balasubramanian A, Jadhav A, Padmanabhan R, Simeonov A, Nath A. Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proc Natl Acad Sci U S A. 2020 Dec 08;117(49):31365–75.
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