CAS: 3563-58-4; 2-Methyl-4-(2,2,2-Trichloro-1-Hydroxyethoxy)Pentan-2-Ol

专利信息

专利号:US-9908876-B2
优先权日:2009-11-05
标 题:Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same
发明人：MILLER MARVIN J; MORASKI GARRETT C; MARKLEY LOWELL D; DAVIS GEORGE E
权利人:UNIV NOTRE DAME DU LAC
摘要:Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.

专利号:US-2012015923-A1
优先权日:2009-03-24
标 题:Use of andrographolide compounds for treating inflammation and airway disorders
发明人：WONG WAI SHIU FRED
权利人:WONG WAI SHIU FRED; UNIV SINGAPORE
摘要:We describe for the first time that andrographolide derivatives such as DDAG effectively reduced OVA-induced inflammatory cell recruitment into BAL fluid, IL-4, IL-5, IL-13 and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion and AHR in a mouse asthma model potentially via inhibition of NF-?B activity. Moreover, low dose of DDAG and glucocorticoid combination treatment synergistically attenuate inflammation in mouse asthma model. These findings support a therapeutic value for DDAG in the treatment of asthma.

专利号:US-10278395-B2
优先权日:2013-03-11
标 题 :Functionalized environmentally benign nanoparticles
发明人：VELEV ORLIN D; RICHTER ALEXANDER P
权利人:UNIV NORTH CAROLINA STATE
摘要:This invention is directed to the preparation and applications of internally and/or externally functionalized environmentally benign nanoparticles (EbNPs), which are produced by a three step procedure: (1) synthesis of native EbNPs, (2) functionalization with active agents, and (3) additional surface property customization via one or more modifier(s).

专利号:US-3954863-A
优先权日:1973-05-08
标题 :Synthesis, polymerization and quaternization of N-substituted acrylamidines
发明人：FUKS ROBERT
权利人:UNION CARBIDE CORP
摘要:N-substituted acrylamidines, a new class of acrylic monomers, are synthesized by the process of this invention which comprises successively contacting with an acrylonitrile or derivative thereof (a) a Lewis acid catalyst, (b) an alkyl halide and (c) an amine. Novel polyacrylamidines as well as quaternary salts of polyacrylamidines are disclosed. Due to their basic nature the N-substituted acrylamidines are useful for introducing basic groups into polymers.

专利号:US-2013149249-A1
优先权日:2010-08-20
标 题 :Imaging tuberculosis with pyrazinamide contrast agents
发明人：KUNIYIL KULANGARA VIJAYA RAJ; HEGDE RAVI
权利人:KUNIYIL KULANGARA VIJAYA RAJ; HEGDE RAVI; GE HEALTHCARE LTD
摘要:The present invention provides novel in vivo imaging agents useful for detecting the presence of mycobacteria using in vivo imaging methods. Also provided by the present invention is a precursor compound useful in the synthesis of the in vivo imaging agents of the invention, and a method to obtain the in vivo imaging agent of the invention using said precursor compound. Methods of in vivo imaging and diagnosis in which the in vivo imaging agent of the invention finds use are also provided.

专利号:US-2013078185-A1
优先权日:2010-05-31
标题:Nitroimidazole derivatives
发明人：KUNIYIL KULANGARA VIJAYA RAJ; ATREYA CHANDAN RAMASWAMY
权利人:KUNIYIL KULANGARA VIJAYA RAJ; ATREYA CHANDAN RAMASWAMY; GE HEALTHCARE LTD
摘要:The present invention provides novel compounds useful in the treatment and diagnosis of mycobacterial infections. Compounds of the present invention have enhanced biological properties as compared to the related known compounds. The present invention also provides a precursor compound useful in the synthesis of certain compounds of the invention, and a method to obtain these compounds using said precursor compound. Methods of treatment and diagnosis in which the compounds of the invention fmd use are also provided.