专利号:US-7737287-B2 优先权日:2002-03-28 标 题 :Anomeric derivatives of monosaccharides 发明人:MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI 权利人:ALCHEMIA LTD 摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.
专利号:US-4416817-A 优先权日:1979-06-08 标题:3-Methoxy-2-oxoazetidine derivatives and their production 发明人:MATSUO TAISUKE; OCHIAI MICHIHIKO 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:Novel 3-methoxy-2-oxoazetidine derivatives, which are shown by the following formula wherein R1 is amino, acylated amino or protected amino, are of value as intermediates for the synthesis of useful compounds represented by the formula wherein R1 has the same meaning as defined above, as drugs in the treatment of bacterial infections.
专利号:US-6982344-B2 优先权日:2000-10-18 标 题:Process for preparation of optically active sulfonamides and intermediates for their synthesis 发明人:IKEMOTO TOMOMI; NISHIGUCHI ATSUKO; TOMIMATSU KIMINORI 权利人:TAKEDA PHARMACEUTICAL 摘要:A method including resolution of a diastereomeric mixture represented by the formula n n nwherein R 1 and R 2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, only one of R 1 and R 2 contains one asymmetric carbon, and R a is an optically active and optionally substituted hydrocarbon group or an optically active and optionally substituted heterocyclic group, or a salt thereof, to produce the diastereomer having a steric configuration of the asymmetric carbon for R 1 or R 2 of an R configuration or an S configuration, or a salt thereof.
专利号:US-10597353-B2 优先权日:2015-11-11 标题:Processes for the preparation of diastereomerically and enantiomerically enriched oxazolines 发明人:BARRECA GIUSEPPE; RASPARINI MARCELLO; CARCONE LUCA; MORANA FABIO 权利人:QUIM SINTETICA S A 摘要:The invention relates to an industrially viable and advantageous process for the preparation of (2S,3 R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, having the following formula (I) generally known as Droxidopa, or of intermediates useful in the synthesis thereof.
专利号:US-2541924-A 优先权日:1948-09-17 标 题 :Synthesis of substituted imidazoles 发明人:JONES REUBEN G 权利人:LILLY CO ELI
专利号:ES-2234908-T3 优先权日:2000-09-14 标题 :PROCEDURE OF SYNTHESIS OF CHIRAL COMPOUNDS.