4-硝基吡啶-N-氧化物置于碳酸氢钠体系中,用 三氯氧磷 用作溶剂,化学反应生成2,4-二氯吡啶 参考文献:Pyridinyl Amides And Imides For Use As Fungicides 标题:Pyridinyl Amides And Imides For Use As Fungicides 摘要:揭示了化合物的化学式(I),它们的n-氧化物和适用于农业的盐,这些化合物可用作杀真菌剂的化合物(I),(II)其中a是取代吡啶基环;B是取代吡啶基环;W是c═l或sonis O或s;R1和r2各自独立地为h;或c1-C6烷基,C2-C6烯基,C2-C6炔基或c3-C6环烷基,每种都可选择地取代;R3为h;或c1-C6烷基,C2-C6烯基,C2-C6炔基或c3-C6环烷基,C2-C6烷基羰基,C2-C6烷氧羰基,C2-C6烷基氨基羰基或c3-C8二烷基氨基羰基;R4为c1-C6烷基,C2-C6烯基,C2-C6炔基或c3-C6环烷基,每种都可选择地取代;X为o或s;N为1或2;条件是当w为c═o且r1,R2和r3为h时;那么b不是4-三氟甲基-3-吡啶基,2-氯-4-吡啶基和2,6-二卤-4-吡啶基之一.还公开了含有化合物的组合物的化学式(I)和一种控制由真菌植物病原体引起的植物病害的方法,该方法涉及施用化合物的有效量的化合物(I).
专利号:US-2025163076-A1 优先权日:2022-02-18 标 题 :Synthesis of bruton's tyrosine kinase inhibitors 发明人:TRAN NGOC DUC; XIOURAS CHRISTOS; CLEATOR EDWARD; MATON WILLIAM MARC; RAMMELOO THOMAS JOACHIM LANDEWALD; FERNANDES PHILIPPE; BONGARTZ JEAN-PIERRE A; CAO DUY CHI TRUNG; HORWITZ MATTHEW ALLAN; JUSSEAU XAVIER JEAN-MARIE; LEMAIRE SÉBASTIEN FRANCOIS-EMMANUEL; SCHWEITZER-CHAPUT BERTRAND 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present disclosure is directed to methods of synthesizing a compound of Formula (I), where the R groups are defined herein, and to methods of synthesizing a compound of Formula (II). Some aspects of the present disclosure is directed to converting the compound of Formula (II) into its P form.
专利号:US-2012328569-A1 优先权日:2010-03-02 标题:Inhibitors of hepatitis c virus ns5b polymerase 发明人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN 权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN 摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:WO-2009073246-A1 优先权日:2007-12-06 标 题 :Method for the synthesis of iridium (iii) complexes with sterically demanding ligands
专利号:US-4920232-A 优先权日:1987-07-10 标 题:α,β-substituted acroleins 发明人:GOETZ NORBERT; KARBACH STEFAN; RECKER HANS-GERT 权利人:BASF AG 摘要:Known and novel substituted acroleins of the general formula I ##STR1## where R 1 is alkoxy, phenoxy, halogen, haloalkyl, haloalkoxy, haloalkylthiyl or nitro, n is an integer from 1 to 5, in the case of n being greater than 1 the R 1 s being identical or different and in the event of nitro substitution the aromatic ring carrying not more than 3 nitro groups, and where R 2 is alkyl, cycloalkyl, unsubstituted or substituted aryl or hetaryl or a nonaromatic heterocyclic radical, are prepared by reacting a phenylacetaldehyde of the general formula II ##STR2## with an aldehyde of the general formula III n n [R.sup.2 -CHO] III n n in the presence of a base and a solvent. These acroleins are useful to prepare hydroxymethyloxiranes which are intermediates in the synthesis of antimycotic and fungicidal azoylmethyloxiranes.
专利号:US-2009124805-A1 优先权日:2006-12-08 标题 :Method for synthesis of iriduim (iii) complexes with sterically demanding ligands
摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 212. 摘要:Ouali, A.; Taillefer, M., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 103. 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026). 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).