CAS: 203120-46-1; (2R,3R,4S)-3-Acetamido-4-Guanidino-2-((1R,2R)-2-Hydroxy-1-Methoxy-3-(Octanoyloxy)Propyl)-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid

上下游产品

(4S,5R,6R)-5-乙酰氨基-4-胍基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-甲酸 Laninamivir 203120-17-6
(2R,3R,4S)-3-Acetamide-4-[2,3-Bis(Tert-Butoxycarbonyl)Guanidino]-2-[(1R,2R)-2,3-Dihydroxy-1-Methoxypropyl]-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid
(4S,5R,6R)-5-乙酰氨基-4-氨基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-羧酸 (2R,3R,4S)-3-Acetamide-4-Amino-2-[(1R,2R)-2,3-Dihydroxy-1-Methoxypropyl]-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid 475483-21-7
Methyl (2R,3R,4S)-3-Acetamide-4-Azide-2-{(S)-Methoxy[(4R)-2-Oxo-1,3-Dioxolan-4-Yl]Methyl}-3,4-Dihydro-2H-Pyran-6-Carboxylate
(3Ar,4R,7Ar)-4-[(1S)-羟基((4R)-2-氧代-1,3-二氧戊环-4-基)甲基]-2-甲基-3A,7A-二氢-4H-吡喃并[3,4-D][1,3]恶唑-6-羧酸甲酯 Methyl (3As,4R,7Ar)-4-{(S)-Hydroxy-((4R)-2-Oxo-1,3-Dioxolan-4-yl)Methyl}-2-Methyl-3A,7A-Dihydro-4H-Pyrano[3,4-D][1,3]Oxazole-6-Carboxylate 1072449-84-3
(2S,4S,5R,6R)-Benzyl 5-Acetamido-2,4-Dihydroxy-6-((1R,2R)-1,2,3-Trihydroxypropyl)Tetrahydro-2H-Pyran-1-Carboxylate 113757-75-8

📜(4S,5R,6R)-5-乙酰氨基-4-氨基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-羧酸置于盐酸,Sodium Hydroxide体系中,用 甲醇,水 用作溶剂,化学反应 51.0H,反应生成辛酸拉尼米韦
参考文献:一种拉尼米韦辛酸酯中间体及其制备方法
标题:一种拉尼米韦辛酸酯中间体及其制备方法
摘要:本发明公开了一种拉尼米韦辛酸酯中间体及其制备方法.所述拉尼米韦辛酸酯中间体12的制备方法包括如下步骤:在溶剂中,在碱的作用下,将拉尼米韦辛酸酯中间体10与化合物19进行如下反应,其中,R为甲基或乙基;X为cl,Br,I,Hso4或h2Po4.本发明的制备方法路线更短,所用试剂更经济,制备成本低,并且后处理简单,适合于工业化生产.

专利信息

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:EP-4192512-A1
优先权日:2020-08-06
标题 :Methods for the synthesis of protein-drug conjugates

专利号:WO-2022032175-A1
优先权日:2020-08-06
标题 :Methods for the synthesis of protein-drug conjugates

专利号:US-2023365608-A1
优先权日:2019-02-01
标 题 :Antiviral nucleosides and derivatives thereof
发明人：BEIGELMAN LEONID; WANG GUANGYI; DYATKINA NATALIA
权利人:JANSSEN BIOPHARMA INC
摘要:Disclosed herein are nucleoside compounds and derivatives thereof, pharmaceutical compositions containing same, and their methods of synthesis. The compounds are useful in treating orthomyxovirus infections, such as influenza infections.

专利号:CN-111116567-B
优先权日:2013-09-09
标题 :Intermediates of zanamivir and lanamivir and their synthesis methods