CAS: 178813-77-9; 2,6-Dichloro-3-Fluorobenzaldehyde

上下游产品

benzylidene dichloride 2,6-dichloro-3-fluorobenzal chloride Methyl formate 1,3-dichloro-4-fluorobenzene ((S)-1-{5-bromo-3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)carbamic acid 9H-fluoren-9-ylmethyl ester ((S)-1-{5-bromo-3-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)carbamic acid 9H-fluoren-9-ylmethyl ester 3-(4-{3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyrazol-1-yl)-azetidine-1-carboxamide 3-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

📜2,6-二氯-3-氟苯乙酮置于sodium Hypochlorite,硼烷四氢呋喃络合物,2,2,6,6-四甲基哌啶氧化物,水,溴,碳酸氢钠,Sodium Bromide,Sodium Hydroxide体系中,用 四氢呋喃,1,4-二氧六环,二氯甲烷,水 用作溶剂,化学反应生成2,6-二氯-3-氟苯甲醛
参考文献: Substituted Pyrrolo[2,3-B]-Pyridines And-Pyrazines[fr] Pyrrolo[2,3-B]-Pyridines Et Pyrrolo[2,3-B]-Pyrazines Substituées
标题: Substituted Pyrrolo[2,3-B]-Pyridines And-Pyrazines[fr] Pyrrolo[2,3-B]-Pyridines Et Pyrrolo[2,3-B]-Pyrazines Substituées
摘要:公式i的化合物,如下所示并在此定义:(I)药用可接受的盐,合成,中间体,配方和治疗疾病的方法,包括至少部分由ron和/或met介导的癌症.

专利信息

专利号:US-2013072495-A1
优先权日:2010-05-14
标 题 :Fused bicyclic kinase inhibitors
发明人：LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G
权利人:LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as but not limited to tumors driven at least in part by at least one of RON, MET, IR, IGF-1R, or ALK. This Abstract is not limiting of the invention.

专利号:US-2014088114-A1
优先权日:2011-05-16
标 题:Fused bicyclic kinase inhibitors
发明人：JIN MEIZHONG; MULVIHILL MARK J; STEINIG ARNO G; WANG JING
权利人:JIN MEIZHONG; MULVIHILL MARK J; STEINIG ARNO G; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula (I), pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of MET, RON, ALK, IR, or IGF-1R. This Abstract is not limiting of the invention.

专利号:US-8592448-B2
优先权日:2008-11-20
标题:Substituted pyrrolo[2,3-b]-pyridines and -pyrazines
发明人：CHEN XIN; JIN MELZHONG; KLEINBERG ANDREW; LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G; WANG JING
权利人:CHEN XIN; JIN MELZHONG; KLEINBERG ANDREW; LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: (I) pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by Ron and/or Met.

专利号:US-8445510-B2
优先权日:2010-05-14
标题 :Fused bicyclic kinase inhibitors
发明人：MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING
权利人:MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.