CAS: 178388-79-9; 3-(1H-Imidazol-2-yl)Propanoicacid

该化合物是一种有机化合物,其特点是其一环和丙基酸功能组;该化合物的特点是五人芳香热循环结构,有助于其生物活动和医药的潜在应用; 氨基苯基酸组(-COOH)的存在允许酸性,使其在水等极溶剂中溶解; 氨基甲酸组可以参与氢与金属离子的结合和协调,增强其回活动性和与生物目标的相互作用; 该化合物经常因其在生物化学途径中的作用而进行研究,并可作为合成更复杂分子的建筑块; 它的独特结构使其能够模拟某些氨基酸,有可能影响蛋白相互作用; 总的来说,3-(1H-imidazol-2-yl)-丙基酸因其结构特征和功能特性,对医药化学和生物化学具有兴趣.

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    专利号:US-6359144-B1
    优先权日:1997-02-04
    标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
    发明人:OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
    权利人:LION BIOSCIENCE AG
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

    专利号:EP-1232166-A2
    优先权日:1999-11-12
    标 题:Synthesis of 2'-deoxy-l-nucleosides

    专利号:US-8389703-B1
    优先权日:2004-08-28
    标 题 :Ribonucleoside analogs with novel hydrogen bonding patterns
    发明人:BENNER STEVEN A; KIM HYO-JOONG
    权利人:BENNER STEVEN A; KIM HYO-JOONG
    摘要:This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. The invention is specifically concerned with nucleotide analogs that present the donor-donor-acceptor, hydrogen bonding patterns on pyrimidine analogs, and especially those that are analogs of ribonucleotides, including protected ribonucleotides suitable for phosphoramidite-based synthesis of RNA. The heterocycles on these nucleoside analogs are aminopyridones that have electron withdrawing groups attached to the position analogous to the 5-position of the ring in standard pyrimidines, including nitro, cyano, and carboxylic acid derivatives.

    专利号:WO-0134618-A2
    优先权日:1999-11-12
    标 题 :Synthesis of 2'-deoxy-l-nucleosides

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    摘要:A. Chakravorty and F.A. Cotton. J. Phys. Chem. 67, 2878 (1963).
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