CAS: 153-97-9; 2-Amino-3-(7-Chloro-1H-Indol-3-yl)Propanoic Acid

该化合物是一种氨酸衍生物,是一种卤化的锥虫,其特点是在蛋白环的7处放置了氯原子.该化合物在生化研究及其在制药和生物化学中的潜在应用中发挥着显著的作用.它具有氨酸的典型特性,包括能够参与peptide联结的形成及其参与蛋白合成.氯原子的存在会影响其再活动及其与生物系统的相互作用,并可能影响酶活动和受体的结合.7-Chrolotryptophan经常被用作各种生物活性化合物合成的建筑块,并可作为研究锥虫及其代谢及其衍生物的工具.此外,它可能由于卤素替代而具有独特的光谱特性,从而在分析化学中有用.与许多卤化化合物一样,由于潜在的环境和健康影响,应注意其处理和处置.

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2070014-72-9 73945-46-7 2382374-53-8

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合成工艺路线路线简述

    📜7-氯吲哚置于盐酸,Sodium Hydroxide,溶剂黄146体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 160.0H,反应生成7-氯色氨酸
    参考文献:Structure-activity Relationship Study Of Novel Necroptosis Inhibitors
    标题:Structure-activity Relationship Study Of Novel Necroptosis Inhibitors
    摘要:Necroptosis Is A Regulated Caspase-Independent Cell Death Mechanism That Results In Morphological Features Resembling Necrosis. It Can Be Induced In A Fadd-Deficient Variant Of Human Jurkat T Cells Treated With Tnf-Alpha. 5-(1H-Indol-3-Ylmethyl)-2-Thiohydantoins And 5-(1H-Indol-3-Ylmethyl)Hydantoins Were Found To Be Potent Necroptosis Inhibitors (Called Necrostatins). A Sar Study Revealed That Several Positions Of The Indole Were Intolerant Of Substitution,While Small Substituents At The 7-Position Resulted In Increased Inhibitory Activity. The Hydantoin Ring Was Also Quite Sensitive To Structural Modifications. A Representative Member Of This Compound Class Demonstrated Moderate Pharmacokinetic Characteristics And Readily Entered The Central Nervous System Upon Intravenous Administration. (C) 2005 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmcl.2005.07.077

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    专利信息


    专利号:US-5817502-A
    优先权日:1994-06-08
    标题 :Genes for the synthesis of pyrrolnitrin

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    合成参考文献


    参考文献:10.1021/bi060607d
    摘要:Yeh E, Cole LJ, Barr EW, Bollinger JM, Ballou DP, Walsh CT. Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. Biochemistry. 2006 Jun 27;45(25):7904–12. doi: 10.1021/bi060607d.
    参考文献:10.1021/bi051706e
    摘要:Howard-Jones AR, Walsh CT. Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. Biochemistry. 2005 Dec 06;44(48):15652–63. doi: 10.1021/bi051706e.
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