CAS: 15205-66-0; 2-(Methylsulfonyl) Ethanol

相似化合物

62020-09-1 2516-97-4 2580-77-0

上下游产品

CAS号5271-38-5 2-甲硫基乙醇 | CAS号75-21-8 环氧乙烷 | CAS号124-63-0 甲基磺酰氯 | CAS号83936-32-7 5-[[2-(methylsu... | CAS号50890-51-2 1-氯-2-(甲基磺酰基)乙烷 | CAS号57903-15-8 2-(甲磺酰)乙基琥珀酰亚胺基碳酸酯 | CAS号50890-51-2 1-氯-2-(甲基磺酰基)乙烷 | CAS号433939-27-6 3-氟-5-溴苯酚 | CAS号191604-52-1 methanesulfonic... | CAS号3680-02-2 甲基乙烯砜 | CAS号16523-02-7 2-溴乙基甲基砜 | CAS号2516-97-4 甲砜基乙酸 | CAS号91290-08-3 2-(METHYLSULFON... | CAS号53298-29-6 2-甲基磺酰基氯甲酸乙酯 | CAS号53298-30-9 碳酸2-(甲基磺酰基)乙酯4-硝基苯酯

2-甲硫基乙醇置于sodium Tungstate (Vi) Dihydrate,双氧水体系中,用 甲醇,水 用作溶剂,以100%的收率获得2-羟乙基甲砜
参考文献:四钼酸四烷基铵 催化剂 用于选择性 氧化作用 硫化物转化为亚砜 过氧化氢
标题:四钼酸四烷基铵 催化剂 用于选择性 氧化作用 硫化物转化为亚砜 过氧化氢
摘要:四钼酸四烷基铵 催化剂 成功应用于选择性 氧化作用 含30%水溶液的各种硫化物转化为亚砜 过氧化氢在温和的反应条件下作为氧化剂,收率为94-100%,选择性为95-100%.这八钼酸盐 催化剂 显示高 催化活性 以高比例的底物 催化剂 (最高10000:1)且可回收,功能活跃 团体,包含 羟 团体和c C键,在氧化作用.
Doi:10.1039/b912521N

专利信息

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:WO-2022220019-A1
优先权日:2021-04-16
标题 :Long-chain dna synthesis using non-natural base
发明人：MASAKI YOSHIAKI
权利人:TOKYO INST TECH
摘要:The purpose of the present invention is to provide a method for synthesizing a long-chain nucleic acid (particularly DNA) with high accuracy. The present invention provides a method for synthesizing a long-chain nucleic acid, the method comprising using: (i) a nucleoside-3'-O-phosphoramidite derivative having a non-natural nucleic acid base; or (ii) a nucleoside-3'-O-phosphoramidite derivative having a non-natural nucleic acid base and a nucleoside-3'-O-phosphoramidite derivative having a natural nucleic acid base in the chemical synthesis of a nucleic acid based on the phosphoramidite method.

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.

专利号:WO-2024061842-A1
优先权日:2022-09-19
标 题:Improved oligonucleotide synthesis
发明人：CREUSEN GUIDO; MINUTH MARCO; SAMSON DANIEL
权利人:BACHEM HOLDING AG
摘要:A method for the solid-phase synthesis of a target oligonucleotide OT is disclosed, wherein said method comprises a step of incubating a nucleoside or oligonucleotide, which is covalently linked to a solid support and comprises a backbone hydroxyl moiety protected by a di(p-methoxyphenyl)phenylmethyl (DMT) protecting group, with a deprotection mixture, thereby cleaving said protecting group from said nucleoside or oligonucleotide, wherein said deprotection mixture is a liquid composition comprising a solvent, a protic acid having a pKa equal to or smaller than 4, and at least one alcohol of Formula (D), wherein in RD-1 R,D-2 R,D-3 RD-4 and RD-5 are indepently of each other selected from the group consisting of H, OH, a e1-e6-alkyl group, O(C1-C6-aIkyl), C(O)(Ci-C6-alkyl), C(O)O(Ci-C6-alkyl), F, Cl, Br, I, and CN. Such a method does not only suppress depurination, but also results in an acceptable product yield.

专利号:WO-2024083746-A1
优先权日:2022-10-17
标 题 :Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.