CAS: 15099-85-1; Dl-฿-Homophenylalanine

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3-[(T-Butoxycarbonyl)Amino]-4-Phenylbutanenitrile置于盐酸,水体系中,化学反应生成3-氨基-4-苯基丁酸
参考文献:Novel Compounds That Inhibit Dipeptidyl Peptidase (Dpp-Iv) And Neprilysin (Nep) And/or Angiotensin Converting Enzyme (Ace)
标题:Novel Compounds That Inhibit Dipeptidyl Peptidase (Dpp-Iv) And Neprilysin (Nep) And/or Angiotensin Converting Enzyme (Ace)
摘要:该发明涉及新型化合物,含有这些化合物的组合物,这些化合物抑制二肽基肽酶(特别是dpp-Iv)和神经肽酶(nep,中性内肽酶)以及二肽基肽酶(特别是dpp-Iv)和血管紧张素转化酶(ace)和/或二肽基肽酶(特别是dpp-Iv)和血管肽酶(特别是ace和nep).这些化合物及其药物组合物对于治疗和预防2型糖尿病是有用的.

专利信息

专利号:CN-104284891-A
优先权日:2012-03-17
标 题:Conformational Restricted Total Synthesis of Macrocyclic Compounds

专利号:CN-116622658-A
优先权日:2022-02-11
标题 :Mutant β-amino acid dehydrogenase and its application in the synthesis of aromatic β-amino acid compounds

专利号:RU-2114829-C1
优先权日:1991-08-12
标题:1,2,4-substituted piperidines and a method of their synthesis, intermedium compounds of piperidone and a method of their synthesis, pharmaceutical composition based on new compounds

专利号:US-8580997-B2
优先权日:2008-07-23
标题 :Process for preparing R-beta-amino phenylbutyric acid derivatives
发明人：SUN PIAOYANG; CHEN YONGJIANG; YU GUANGLIANG
权利人:SUN PIAOYANG; CHEN YONGJIANG; YU GUANGLIANG; JIANGSU HENGRUI MEDICINE CO
摘要:Disclosed is a process for preparing single enantiomers of beta-amino phenylbutyric acid derivatives and pharmaceutically acceptable salts thereof, which affords the desired compounds having special optical configuration. The process comprises a step of chemical synthesis and a step of resolving the optical isomers of beta-amino phenylbutyric acid derivatives with a resolving agent. The resolving step comprises reacting the optical isomers with resolving agents, such as di-para-toluoyl-L-tartaric acid and di-para-toluoyl-D-tartaric acid. The obtained R-beta-amino phenylbutyric acid derivatives (I) have high optical purity, and the total yield of the accumulative resolution of the laevo and the dextro isomer is up to above 70%.