CAS: 119831-72-0; Fmoc-Arg(Pmc)-Oh

该化合物是五甲基铬化合物的全氟辛烷磺酸衍生物.该物质通常具有氟化甲基氧碳基(Fmoc)保护组,通常用于peptide合成以保护氨基化合物群.全氟辛烷磺酸组的存在表明,该物质在水中很可能高度溶解,在生物应用方面加强其效用.五甲基铬结构表明,该物质可能具有抗氧化性特性,因为铬人因有能力进行脱硫自由基体而闻名.此外,甲基组的具体安排可能会影响该化合物的消毒性和电子特性,从而可能影响其与生物目标的抗反应和相互作用.

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合成工艺路线路线简述

    📜2,3,5-三甲基苯酚置于palladium On Activated Charcoal 氯磺酸,Sodium Hydroxide,氢气,Sodium Carbonate,Zinc(II) Chloride体系中,用 甲醇,氯仿,溶剂黄146,N,N-二甲基甲酰胺,丙酮 用作溶剂,化学反应 25.25H,反应生成Nα-Fmoc-Nω-(2,2,5,7,8-五甲基苯并二氢吡喃-6-磺酰基)-L-精氨酸
    参考文献:用于肽合成的酸不稳定的精氨酸衍生物:N G-2,2,2,5,7,8-五甲基苯并吡喃-6-磺酰基-L-精氨酸
    标题:用于肽合成的酸不稳定的精氨酸衍生物:N G-2,2,2,5,7,8-五甲基苯并吡喃-6-磺酰基-L-精氨酸
    摘要:已经开发出用于精氨酸的胍侧链功能的三氟乙酸(tfa)不稳定的保护基.ñ ģ-(2,2,5,7,8-五甲基-6-磺酰基-L-精氨酸在室温下迅速裂解以tfa或50%tfa的二氯甲烷溶液fmoc.Arg(pmc).oh的制剂和描述了bnpeoc.Arg(pmc).Oh.
    Doi:10.1016/s0040-4020(01)86564-9

    海关参考信息

    专利信息


    专利号:US-2007179279-A1
    优先权日:2005-12-30
    标题:Methods for the synthesis of arginine-containing peptides
    发明人:CHEN LIN; ROBERTS CHRISTOPHER R
    权利人:CHEN LIN; ROBERTS CHRISTOPHER R
    摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.

    专利号:US-6316593-B1
    优先权日:1996-02-09
    标题:Synthesis of VIP analog
    发明人:BOLIN DAVID ROBERT; DANHO WALEED; FELIX ARTHUR M
    权利人:HOFFMANN LA ROCHE
    摘要:This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)-NH2 from four protected peptide fragments.

    专利号:WO-9106558-A1
    优先权日:1989-10-25
    标题 :Process for peptide synthesis and vehicles therefor
    发明人:FRANK RONALD; KRAUSE SUSANNE
    权利人:BIOTECHNOLOG FORSCHUNG GMBH
    摘要:The invention concerns a process for the fast and, where appropriate, simultaneous synthesis of peptides and suitable rod-like vehicles therefor.

    专利号:US-6316595-B1
    优先权日:1994-03-14
    标题 :PNA synthesis using a base-labile amino protecting group
    发明人:BREIPOHL GERHARD; UHLMANN EUGEN; KNOLLE JOCHEN
    权利人:AVENTIS PHARMA GMBH
    摘要:The invention provides compounds and processes for synthesis of peptide nucleic acids (PNA). The compounds include temporary amino protecting groups that are base-labile, and protection groups for the exocyclic amino function of the nucleotide base that is compatible with the base-labile amino protecting group. Cleavage of an oligomer comprising these compounds from a solid support can be achieved using weak or medium strength acids.

    专利号:US-2005100968-A1
    优先权日:2000-02-23
    标题 :Self-encoded combinatorial synthesis of compound multiplets
    发明人:GALLOP MARK A; DOWER WILLIAM J; BARRETT RON W
    权利人:XENOPORT INC
    摘要:The present invention provides a variety of methods for synthesizing, encoding and decoding compounds in a combinatorial library. One step or cycle in the synthetic methods of the invention is a self-encoding step in which different pairs of components, each pair with a known and different molecular weight difference, are reacted with supports, whereby two compounds differing in molecular weight are formed on each support. The molecular weight difference between the two compounds on the support encodes for a particular component pair. Libraries of compounds formed according to the methods of the invention are also provided.

    专利号:US-6569993-B1
    优先权日:1998-04-15
    标题 :Process for the preparation of resin-bound cyclic peptides
    发明人:SLEDESKI ADAM W; MENCEL JAMES J
    权利人:AVENTIS PHARMA SA
    摘要:This invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-related proteins, which analogs contain at least one bridge between the side chains of two non-adjacent amino acid residues, and to peptide fragments useful therefor.

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    合成参考文献


    参考文献:10.1016/s0968-0896(97)00078-3
    摘要:Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz de Montellano PR. The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease. Bioorganic & Medicinal Chemistry. 1997 Jul;5(7):1311–20. doi: 10.1016/s0968-0896(97)00078-3.
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