CAS: 1143516-05-5; 17-Amino-10-Oxo-3,6,12,15-Tetraoxa-9-Azaheptadecan-1-Oic Acid

相似化合物

560088-89-3 1069067-08-8 846549-37-9

上下游产品

2,2-dimethyl-4,13-dioxo-3,8,11,17,20-pentaoxa-5,14-diazad°Cosan-22-oic acid

2,2-二甲基-4,13-二氧代-3,8,11,17,20-五氧杂-5,14-二氮杂二十二烷-22-油酸置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应生成17-氨基-10-氧代-3,6,12,15-四氧杂-9-氮杂十七烷酸
参考文献:一种通用的即用型异三功能交联剂,可轻松合成获得复杂的生物缀合物† ‡
标题:一种通用的即用型异三功能交联剂,可轻松合成获得复杂的生物缀合物† ‡
摘要:我们首次描述了带有三个完全相互兼容的生物正交功能基团的原始异三功能交联剂(也称为三脚架)的合成和某些生物缀合应用.与我们最近报道的第一代三脚架相反(org.生物摩尔.化学,2008,6,3065),使用叠氮基取代的亲核试剂敏感的活性氨基甲酸酯分子部分使我们能够达到目标化学正交性,而无需使用临时的氨氧基和硫醇保护基.因此,通过三脚架的连续衍生,通过铜介导的1,3-偶极环加成,肟连接和与水相容的轻度硫醇烷基化反应明显更简单,更方便.化学选择性生物缀合方案是通过基于fret盒的制备而优化的花青 和/或 An吨荧光染料对以及随后锚定到易碎的生物分子上.该通用交联剂的适用性还通过通过spit-Fri方法制备适合检测黄曲霉毒素b1的生物芯片来说明.
Doi:10.1039/c0Ob00133C

专利信息

专利号:WO-2023012709-A1
优先权日:2021-08-05
标 题 :An improved process for fmoc synthesis of semaglutide
发明人：LOBO LESTER JOHN; CHANDRAKESAN MURALIDHARAN; DOSHI CHETAN; CHANADAK SHAILESH LALCHAND; YADAV NANDLAL GOPAL; MOHE NIKHIL UMESH; VISHWANATHAN KODANDARAMAN
权利人:USV PRIVATE LTD
摘要:The present invention relates to an improved process for the synthesis of glucagon-like-peptide-1 (GLP-1) and its analogs by using combination of solid and solution phase synthesis of Fmoc protected amino acids in a sequential manner, optionally incorporating Boc protected dipeptide for unnatural amino acid in the Sequence of GLP-1, cleaving GLP-1 sequence from the resin followed by purification; attaching side-chain to the desired amino acid in the solution phase to synthesize desired GLP-1 analog, purifying it to Semaglutide. Temperature gradient is applied during initial coupling of amino acids to facilitate completion of difficult coupling reactions.

专利号:US-10920258-B2
优先权日:2018-03-09
标题 :Chemo-enzymatic synthesis of semaglutide, liraglutide and GLP-1
发明人：NUIJENS TIMO; TOPLAK ANA; QUAEDFLIEG PETER JAN LEONARD MARIO
权利人:ENZYPEP B V
摘要:A method for synthesizing a peptide having the sequence His-X-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Y-Glu-Phe-Ile-Ala-Trp-Leu-Val-Z-Gly-Arg-Gly is disclosed. The method includes enzymatically coupling:n (a) a peptide C-terminal ester or thioester having a first peptide fragment with the sequence His-X-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-(thio)ester; and (b) a peptide nucleophile having an N-terminally unprotected amine having a second peptide fragment with the sequence H-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Y-Glu-Phe-Ile-Ala-Trp-Leu-Val-Z-Gly-Arg-Gly; wherein:n X is Ala or an α-amino-isobutyric acid (Aib) residue; Y is Lys, which Lys has a free side-chain ε-amino group or of which Lys the side-chain ε-amino group is protected with a protective group or of which Lys the side-chain ε-amino group is functionalized with an amino acid or another functional group; and Z is Arg or Lys.

专利号:WO-2023105497-A1
优先权日:2021-12-10
标题:Synthesis of glp-1 analogues
发明人：GODHA ATUL KASTURCHAND; NARAYANASWAMY SATHYA VANGANUR; BHAGYARAJ ARETI VENKATA; BAVADEKAR ASLAM JAHANGIR; LAKSHMANAPPA RUDRESH; NAGOOR SHEIKSYEDALI; MURUGAN RANJITHKUMAR; GADAKH AMOL VASANTRAO; SAMBASIVAM GANESH
权利人:ANTHEM BIOSCIENCES PVT LTD
摘要:The present invention provides a method of preparation of GLP-1 peptides by using different peptide fragments having amino acid sequences SEQ ID NO:1 (Fragment IG), SEQ ID NO:2 (Fragment SG), Fragment BG, SEQ ID NO:3, and SEQ ID NO:4 5 and combinations thereof. The method of preparation is environmentally benign, simple, straightforward, and efficient and provides the end product in high yield and purity. The purification method of the peptides is also described.

专利号:US-2020262886-A1
优先权日:2018-03-09
标 题 :Chemo-enzymatic synthesis of semaglutide, liraglutide and glp-1

专利号:CN-111757891-A
优先权日:2018-03-09
标题 :Chemo-enzymatic synthesis of semaglutide, liraglutide and GLP-1

专利号:WO-2025078040-A1
优先权日:2023-10-09
标 题 :Lysine salt and method of manufacturing a lysine derivative
发明人：HINTERMANN TOBIAS; SCHWINDLING JOACHIM; RÃœEFLI PASCAL; SCHÖNLEBER RALPH O; WILLIG FELIX; MELZIG LAURIN; ERMERT PHILIPP; KÃœMIN MICHAEL; SCHWIZER NATASCHA; SCHNEIDER ANGELIKA; SCHMID LUCIUS
权利人:BACHEM HOLDING AG
摘要:The invention relates to a Bsmoc-protected lysine salt of formula (1 X ), e.g., a hydrochloric acid salt (n = 1, HY = hydrochloric acid). It further relates to a method of manufacturing Bsmoc-protected lysine derivatives, which employs the Bsmoc-protected lysine salt of formula (1 X ) and comprises the step of reacting the epsilon amino group of lysine with an 10 activated carboxylic acid derivative. Some of the obtainable Bsmoc-protected lysine derivatives with their side chain modification are useful as starting materials in solid phase peptide synthesis.