专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
专利号:CN-103534238-B 优先权日:2011-03-29 标题 :Total synthesis of redox-active 1.4‑naphthoquinone and its metabolites and their therapeutic use as antimalarial and schistosicides
专利号:US-9446047-B2 优先权日:2013-09-10 标 题 :Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis 发明人:VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY 权利人:ARRIEN PHARMACEUTICALS LLC 摘要:The present invention is directed to compounds, their synthesis, and their use as antagonists, inverse agonists, modulators and or inhibitors of the Retinoic acid-related orphan nuclear receptor γt (RORγt)/RORγ. The compounds of the present invention are useful for modulating RORγt)/RORγ activity and for treating diseases or conditions mediated by RORγt)/RORγ such as for example, disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.
专利号:TR-201607376-A2 优先权日:2016-06-01 标 题:SYNTHESIS AND ANTIPROLIFERATIVE EFFECTS OF FLOR ATOMA (1,3 DIARYL) -2-PROPEN-1-ON DERIVATIVE COMPOUNDS
参考标题:Synthesis And Anti-Bacterial Properties Of Mono-Carbonyl Analogues Of Curcumin 作者:Guang Liang,Shulin Yang,Lijuan Jiang,Yu Zhao,Lili Shao,Jian Xiao,Faqing Ye,Yueru Li,Xiaokun Li 摘要:The Synthesis Of Three Series Of Curcumin Analogues With Mono-Carbonyl Is Described. Their In Vitro Anti-Bacterial Activities Against Seven Gram-Positive And Gram-Negative Bacteria Were Tested And The Effect Of Substituents On The Aryl Ring And The Space Structure Of The Linking Strain Were Discussed. It Was Observed That Part Of The Derivatives Displayed Significant Activity When Compared With Curcumin And Most Of Them Exhibited Activity Against The Ampicillin-Resisted Enterobacter Cloacae. Compounds A12, B09, B13, B14 And C09 Show Remarkable Antibacterial Activity In Vitro. The Result Showed That Heterocycle Or Long-Chain Substituents May Enhance The Activity Of Curcumin Analogues.