CAS: 104091-09-0; Fmoc-D-Glu-Oh
该化合物是D-glutamic酸的一种受保护衍生物,其特点是N终点的Fmoc(9-氟戊基甲基苯氧碳基)组,该化合物广泛用于固相酸合成(SPPS),因为它在引入D-glutamic酸残留物的同时,确保正统保护战略.Fmoc组在温和的基本条件下提供选择性的去保护,保护酸性实验室的侧链保护.它的高度纯度和稳定性使它适合精确的peptide链组装,特别是在合成抗生素性纯皮片或聚苯乙烯片中.D-conformation对酶降解具有抗药性,加强其在生物医学研究与药物开发中的效用.建议在水下进行适当处理以保持完整性.
- 英文名称Fmoc-D-Glu-Oh
- 中文名称(((9H-芴-9-基)甲氧基)羰基)-D-谷氨酸
- IUPAC名称(((9H-fluoren-9-yl)methoxy)carbonyl)-D-glutamic acid
- 其它别名N-Fmoc-D-Glutamic Acid; Fmoc-D-Glutamic Acid; Qepwhixhjnnglu-Qgzvfwflsa-N; N-{[(9H-Fluoren-9-yl)Methoxy]Carbonyl}-D-Glutamic Acid; Fmoc-D-Glu-Oh
- CAS编号104091-09-0
- MFCD编号:MFCD09037362
- FDA UNII编号:UK978U3STK
- 分子式:C20H19NO6分子量:369.37
- 产品CID: 79050
- 产品分类有机原料→生命科学→氨基酸及其衍生物→谷氨酸及其衍生物
相似化合物
1155-62-0 121343-82-6 138-15-8物理性质
MSDS等安全信息
上下游产品
CAS号71989-18-9 Fm°C-O-叔丁基-L-谷氨酸 | CAS号56-86-0 L-谷氨酸 | CAS号1131148-55-4 N-Fm°C-1H-benzo... | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号2387-23-7 N,N’-二环己基脲 | CAS号104091-10-3 Fm°C-D-Glu benz... | CAS号104091-11-4 Fm°C-D-谷氨酸-苄酯 | CAS号104091-08-9 N-芴甲氧羰基-D-谷氨酸 g... | CAS号144120-54-7 N-芴甲氧羰基-L-谷氨酸 1-烯丙基酯合成工艺路线路线简述
📜D-谷氨酸置于碳酸氢钠体系中,用 氘代丙酮,水 用作溶剂,以81%的收率获得n-(9-芴甲氧羰基)-D-谷氨酸
参考文献:Chemical Synthesis And Anti-Tumor And Anti-Metastatic Effects Of Dual Functional Conjugate
标题:Chemical Synthesis And Anti-Tumor And Anti-Metastatic Effects Of Dual Functional Conjugate
摘要:本发明披露了一种双重功能的共轭物的化学合成,抗肿瘤和抗转移作用,如公式i所示.具体来说,紫杉醇或多西他赛与杆菌二肽衍生物结合形成共轭物,从而通过化疗和免疫疗法的结合实现双重抗肿瘤和抗转移作用.本发明还披露了紫杉醇或多西他赛和杆菌二肽衍生物共轭物的合成是通过固相和溶液相合成的组合实现的,并且所述共轭物可以用于制造抗肿瘤药物,这已经通过可靠的生物测定证明.
海关参考信息
- 2905130000-正丁醇
2905399099-其他二元醇
2905499000-其他多元醇
2905590090-其他无环醇的卤化、磺化等衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9085605-B2
优先权日:2010-05-27
标 题:Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
发明人：LIU GANG; ZHAO NAN; MA YAO
权利人:LIU GANG; ZHAO NAN; MA YAO; SHENZHEN SALUBRIS PHARM CO LTD
摘要:The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as shown by formula I. Specifically, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.
专利号:US-11879038-B2
优先权日:2019-09-09
标 题 :Supramolecular gel supported on open-cell polymer foam
发明人：JIERRY LOÃ C; SERRA CHRISTOPHE; SCHAAF PIERRE; RODON FORES JENNIFER; BOULMEDAIS FOUZIA
权利人:UNIV STRASBOURG; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED
摘要:The present invention relates to a polymer foam, said polymer foam comprising pores forming an open-cell polymer foam, said polymer foam comprising a supramolecular gel inside pores, and said polymer foam comprising at least one enzyme. The present invention relates to a supramolecular gel; its preparation and its applications, notably in chemical synthesis and kinetic resolution, in particular of organic compounds. The present invention also relates to flow chemistry.
专利号:EP-3239139-B1
优先权日:2010-05-27
标题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
专利号:US-2013143826-A1
优先权日:2010-05-27
标 题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
专利号:JP-2013529218-A
优先权日:2010-05-27
标 题:Chemical synthesis and anti-tumor and anti-tumor metastatic effects of dual functional conjugates
专利号:WO-2011147330-A1
优先权日:2010-05-27
标题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: Rodon Fores J, Et Al. Supported Catalytically Active Supramolecular Hydrogels For Continuous Flow Chemistry. Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18817-18822.合成参考文献
参考文献:10.1007/s00259-007-0582-3
摘要:Knör S, Sato S, Huber T, Morgenstern A, Bruchertseifer F, Schmitt M, Kessler H, Senekowitsch-Schmidtke R, Magdolen V, Seidl C. Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in α-emitter therapy for disseminated ovarian cancer. European Journal of Nuclear Medicine and Molecular Imaging. 2007 Sep 22;35(1):53–64. doi: 10.1007/s00259-007-0582-3.
📝 需求与反馈
尽可能描述清楚需求与问题信息
