CAS: 6358-77-6; 5-Bromo-2-Methoxyaniline

上下游产品

2-氨基-4-溴苯酚 2-Amino-4-Bromo-Phenol 40925-68-6
4,5-二溴-2-甲氧基-苯基胺 4,5-Dibromo-2-Methoxy-Phenylamine 367521-06-0
4-溴-2-硝基苯甲醚 4-Bromo-1-Methoxy-2-Nitrobenzene 33696-00-3
2-乙酰氨基-4-溴苯甲醚 N-(5-Bromo-2-Methoxyphenyl)Acetamide 88301-40-0
4-溴苯甲醚 1-Bromo-4-Methoxy-Benzene 104-92-7

4-溴-2-硝基苯酚置于盐酸,Tin,Potassium Carbonate体系中,用 氘代丙酮,乙醇,水 作为反应溶剂,化学反应 8.0H,反应生成 5-溴-2-甲氧基苯胺
参考文献:Tubulin Binding Agents
标题:Tubulin Binding Agents
摘要:该发明提供了类似于康柏他定a-4的化合物,经过改良以增强微管结合活性,在某些实施例中还具有促进在进行血管反应生成的血管系统中积聚(归巢活性)的能力.这些化合物基于康柏他定a-4的骨架结构,其具有一个微管结合药效团,包括两个融合环(a环和b环),其中b环被取代为(a)芳香环结构(c环)和(b)从b环上脱落的第二取代基/官能团.芳香环结构通常是一个六元环酚或苯胺结构,也可以是一个融合环结构,如取代或未取代的萘.b环上的第二取代基可以是已知可提供增强微管结合活性的取代基(例如酰基),也可以是促进b环官能化的取代基(例如羟基或胺基),或者可以是一种针对在进行血管反应生成的血管系统上优先表达而在静止血管系统上不表达的靶标的结合剂.

专利信息

专利号:CN-119899171-A
优先权日:2024-09-26
标 题:Synthesis of PROTACs compound containing pure carbon chain targeting ACLY and application of compound in aspect of resisting NASH

专利号:WO-2012172449-A1
优先权日:2011-06-13
标题:Lactams as beta secretase inhibitors
发明人：BRODNEY MICHAEL AARON
权利人:PFIZER; BRODNEY MICHAEL AARON
摘要:Compound and pharmaceutically acceptable salts of the compound are disclosed, wherein the compound has the structure (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. The compound of formula I is useful as beta secretase inhibitor for use in the treatment of Alzheimer's and other neurodegenerative and/or neurological disorders.