CAS: 57982-78-2; 1-(Tert-Butyl)-4,4-Diphenylpiperidine

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CAS号1465-76-5 1-(叔丁基)哌啶-4-酮 | CAS号71-43-2 苯

合成工艺路线路线简述

    📜1-叔丁基哌啶-4-酮,苯置于三氯化铝体系中,化学反应 2.0H,反应生成 叔丁哌苯
    参考文献:Schaefer; Hackmack; Eistetter,Arzneimittel-Forschung/drug Research,1984,Vol. 34,# 3,P. 233-240
    标题:Schaefer; Hackmack; Eistetter,Arzneimittel-Forschung/drug Research,1984,Vol. 34,# 3,P. 233-240

    海关参考信息

    专利信息


    专利号:US-2009285888-A1
    优先权日:2005-05-13
    标题:Derivatives of dihydroxyphenylalanine
    发明人:SUSILO GISELA
    权利人:SUSILO GISELA
    摘要:The invention relates to derivatives of dihydroxyphenylalanine, to their synthesis and to pharmaceutical compositions containing said derivatives of dihydroxyphenylalanine. Furthermore, the invention relates to the use of said derivatives of dihydroxyphenylalanine and said pharmaceutical compositions for the treatment and prophylaxis of movement disorders, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, hemiparkinson-hemiatrophy, parkinsonian syndrome, Lewy body disease, frontotemporal dementia, Lytico-Bodig disease (parkinsonism/dementia/amyotrophic lateral sclerosis), striatonigral degeneration, Shy-Drager syndrome, sporadic olivopontocerebellar degeneration, progressive atrophy of the globus pallidus, progressive supranuclear palsy, Hallervorden-Spatz disease, Huntington's disease, X-linked dystonia-parkinsonism (Lubag), mitochondrial cytopathy with striatal necrosis, neuroacanthocytosis, restless legs syndrome, Wilson's disease.

    专利号:EP-4630405-A1
    优先权日:2022-12-06
    标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

    专利号:WO-2024123815-A1
    优先权日:2022-12-06
    标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

    专利号:US-2007148246-A1
    优先权日:2005-08-11
    标题:Nucleic Acid-Based Matrixes
    发明人:LUO DAN; LI YOUGEN
    权利人:LUO DAN; LI YOUGEN
    摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:US-8486621-B2
    优先权日:2005-08-11
    标题 :Nucleic acid-based matrixes
    发明人:LUO DAN; UM SOONG HO
    权利人:LUO DAN; UM SOONG HO; CORNELL RES FOUNDATION INC
    摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include cell-free protein synthesis.

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    合成参考文献


    参考文献:10.1007/s007020050159
    摘要:Hagenah J, Klein C, Sieberer M, Vieregge P. Exogenous levodopa is not toxic to elderly subjects with non-parkinsonian movement disorders: further clinical evidence. J Neural Transm (Vienna). 1999;106(3-4):301–7. doi: 10.1007/s007020050159.
    参考文献:10.1016/j.jns.2006.05.039
    摘要:Reichmann H. Budipine in Parkinson's tremor. Journal of the Neurological Sciences. 2006 Oct;248(1-2):53–5. doi: 10.1016/j.jns.2006.05.039.
    参考文献:10.1007/bf01249078
    摘要:Russ H, Pindur U, Przuntek H. The interaction of 1-alkyl-4, 4-diphenylpiperidines with the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine receptor binding site. Journal of Neural Transmission. 1986 Sep;65(3-4):157–66. doi: 10.1007/bf01249078.
    参考文献:10.1007/s001080050460
    摘要:Gasser T. [Current pharmacologic therapy of idiopathic Parkinson's syndrome]. Internist (Berl). 1999 Nov;40(11):1228–35. doi: 10.1007/s001080050460.
    参考文献:10.1016/s0924-9338(99)00153-4
    摘要:Rudolf J, Ghaemi M, Schmülling S. Deterioration of parkinsonian symptoms following treatment of dopaminergic hallucinosis with olanzapine. Eur Psychiatry. 1999 Oct;14(6):356–7. doi: 10.1016/s0924-9338(99)00153-4.
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