CAS: 57946-63-1; 2-Bromo-4-(Trifluoromethyl)Aniline

上下游产品

CAS号455-14-1 4-氨基三氟甲苯 | CAS号117324-58-0 2-氨基-5-三氟甲基苯甲酸甲酯 | CAS号6526-08-5 2-氨基-5-三氟甲基苯腈 | CAS号175135-49-6 N-(2-溴-4-三氟甲基苯基)乙酰胺 | CAS号78060-56-7 2-氯-6-(三氟甲基)喹啉 | CAS号481075-58-5 3-溴-4-碘三氟甲苯

对三氟甲基苯胺置于sodium Hydrogensulfate Monohydrate,4-(2-苯基-1-乙炔)苯甲腈,水,Sodium Bromide体系中,用 乙腈 作为反应溶剂,化学反应 24.0H,以80%的收率获得产物4-氨基-3-溴三氟甲苯
参考文献:可见光促进(杂)芳烃的氧化卤化
标题:可见光促进(杂)芳烃的氧化卤化
摘要:有机卤化物是参与各种交叉偶联反应的重要组成部分.此外,它们作为具有重要生理活性的药物中的天然产物和人工分子广泛存在.尽管已经对卤化进行了充分的研究,但据我们所知,还没有报道过针对敏感系统(例如芳基胺)的研究.在此,我们描述了在环境条件(可见光,空气,水系统,室温和常压)下,(杂)芳烃与空气作为氧化剂和卤离子作为卤化物源的相容性氧化卤化作用.而且,该协议对于克级合成实际上是可行的,显示出工业应用的潜力.
DOI:10.1039/d0Gc02091E

专利信息

专利号:EP-1607389-A1
优先权日:1999-09-10
标题:4-protected-amino-2-substituted-1,2,3,4-tetrahydroquinolines as intermediates for CETP inhibitors
发明人：DENINNO MICHAEL PAUL; MAGNUS-ARYITEY GEORGE TETTEH; RUGGERI ROGER BENJAMIN; WESTER RONALD THURE
权利人:PFIZER PROD INC
摘要:The present invention relates to compounds of formulan nwherein P 2 , R 2 , R 5 , R 6 , R 7 and R 8 are as defined herein, which are useful as intermediates innthe synthesis of 4-carboxyarnino-2-substitated-1,2,3,4-tetrahydroquinolines.

专利号:US-2016229847-A1
优先权日:2013-10-04
标 题:Novel bicyclic pyridinones as gamma-secretase modulators
发明人：PETTERSSON MARTIN YOUNGJIN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; JOHNSON DOUGLAS SCOTT; KAUFFMAN GREGORY WAYNE; O'DONNELL CHRISTOPHER WILLIAM; PATEL NANDINI CHATURBHAI; STEPAN ANTONIA FRIEDERIKE; STIFF CORY MICHAEL; SUBRAMANYAM CHAKRAPANI; TRAN TUAN PHONG; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula II as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-112028826-B
优先权日:2020-10-12
标 题 :Synthesis method of 6- (trifluoromethyl) quinoline-8-carboxylic acid