📜N-Cbz-甘氨酸乙酯置于一水合肼体系中,用 甲醇 作为反应溶剂,化学反应 1.33H,反应生成 Cbz-甘氨酸酰肼
参考文献:New System For Peptide Synthesis Using N-Acylpyrazoles
标题:New System For Peptide Synthesis Using N-Acylpyrazoles
摘要:New System Of Peptide Synthesis Was Described. The Extension Of One Amino Acid Unit On The Peptide Chain Was Constituted From Only 2 Reaction Steps,The Conversion From Esters To The Corresponding N-Acylpyrazoles And The Subsequent Aminolysis With Amino Esters. This New System Was Distinctive From The Conventional Peptide Synthesis,Which Was Consisted Of 3 Steps Of The Deprotection,The Activation And The Condensation. Moreover,The Key Intermediate N-Acylpyrazoles Exhibited The Excellent Properties Of High Sensitivity And Separability For The Chiral Column On HPLC Using The Uv Detector.
DOI:10.3987/com-99-S51