CAS: 499-61-6; 2-Amino-1-(3,4-Dihydroxyphenyl)Ethan-1-One

相似化合物

5090-29-9 55-27-6 16899-81-3

上下游产品

2-chloro-3',4'-dihydroxyacetophenone N-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)benzamide 2-dibenzylamino-1-(3,4-dihydroxy-phenyl)-ethanone 2-azido-1-(3,4-dihydroxy-phenyl)-ethanone 2-oxo-N-acetyldopamine Norepinephrine N-[2-(3,4-dihydroxy-phenyl)-1-hydroxymethyl-2-oxo-ethyl]-acetamideN-[2-(3,4-dihydroxy-phenyl)-1-hydroxymethyl-2-oxo-ethyl]-acetamide α-(t-butyloxycarbonyl)amino-3,4-dihydroxyacetophenone

📜2-Hydroxy-4-[2-(3,5,7-Triaza-1-Azoniatricyclo[3.3.1.13,7]Decan-1-yl)Acetyl]Phenolate;Hydrochloride置于盐酸体系中,用 甲醇,水,异丙醇 作为反应溶剂,化学反应 4.0H,以96.3%的收率获得产物2-氨基-1-(3,4-二羟基苯基)乙烷-1-酮
参考文献: Process For Preparation Of (Dl)-Norepinephrine Acid Addition Salt,A Key Intermediate Of (R)-(-)-Norepinephrine[fr] Procédé De Préparation D'Un Sel D'Addition D'Acide De Norépinéphrine (Dl),Intermédiaire Clé De La Norépinéphrine (R)-(-)-
标题: Process For Preparation Of (Dl)-Norepinephrine Acid Addition Salt,A Key Intermediate Of (R)-(-)-Norepinephrine[fr] Procédé De Préparation D'Un Sel D'Addition D'Acide De Norépinéphrine (Dl),Intermédiaire Clé De La Norépinéphrine (R)-(-)-
摘要:该发明揭示了一种制备(Dl)-去甲肾上腺素盐的方法,通过将3,4-二羟基-α-卤代乙酰苯酮与六亚甲基四胺反应以提供六胺盐;随后进行水解和氢化.该发明还揭示了该过程中形成的一种新型中间体及其合成方法.

专利信息

专利号:WO-2025058704-A1
优先权日:2023-09-15
标 题:Process for the preparation of epinephrine and norepinephrine
发明人：YUE TAI-YUEN; SAHANI RAJKUMAR; JAYARAMAN ARAVINDAN; DONSBACH KAI; SENANAYAKE CHRIS; QU BO; SIRASANI GOPAL; MANGUNURU HARI; JANGANATI VENUMADHAV; GANGU ARAVIND; TERRAB LEILA; KALIKINIDI NAGESWARA
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:A method of preparing epinephrine or norepinephrine is provided. The method includes reacting a starting material comprising 2-chloro-l-(3,4-dihydroxyphenyl)ethan-l- one with an amine nucleophile RNH2 (R=H for the synthesis of epinephrine or Me for the synthesis of norepinephrine) under conditions suitable for nucleophilic substitution of the starting material to form a substituted starting material and reacting the substituted starting material with a tethered ligand transition metal catalyst under conditions suitable for transfer¬ hydrogenation to produce epinephrine or norepinephrine.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:WO-2013008247-A1
优先权日:2011-07-13
标题:Process for preparation of (dl) -norepinephrine acid addition salt, a key intermediate of (r) - (-) - norepinephrine
发明人：DALVI MAHESH BHAGOJI; KENNY RAJESH SHASHIKANT; KAWLE GANESH RAMACHANDRA
权利人:NEON LAB LTD; DALVI MAHESH BHAGOJI; KENNY RAJESH SHASHIKANT; KAWLE GANESH RAMACHANDRA
摘要:The invention discloses a process for preparation of (dl)-norepinephrine salt by reacting 3,4-dihydroxy-a-haloacetophenone with hexamethylenetetramine to provide hexamine salt; followed by hydrolysis and hydrogenation. The invention also discloses a novel intermediate formed in the process and its synthesis.

专利号:CN-115073312-A
优先权日:2022-07-15
标题 :A new method for the synthesis of norepinephrine bitartrate

专利号:US-5047592-A
优先权日:1989-08-21
标题 :Selective hydrogenolysis process
发明人：CARPENTER JOEL F
权利人:ETHYL CORP
摘要:A relatively simple, economical process for the synthesis of epinine and related compounds is described. The process involves subjecting adrenalone, epinephrine or their respective congeners to selective hydrogenolysis using hydrogen and a metal hydrogenolysis catalyst such as palladium, platinum, rhodium or nickel. Preferably the reaction is conducted in a non-oxidizing acidic liquid reaction medium, such as in aqueous hydrochloric acid.

专利号:CN-111019981-A
优先权日:2019-12-27
标题:Asymmetric synthesis of R-norepinephrine