CAS: 45214-91-3; (S)-2-((Tert-Butoxycarbonyl)Amino)-5-Methoxy-5-Oxopentanoic Acid

相似化合物

76379-01-6 145038-50-2 1499-55-4

上下游产品

CAS号1499-55-4 L-谷氨酸-5-甲酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号132245-78-4 (S)-2-叔丁氧基羰基氨基-... | CAS号3077-51-8 (S)-2-氨基-5-甲氧基-... | CAS号34619-03-9 碳酸二叔丁酯 | CAS号24277-38-1 (S)-1-叔丁基5-甲基2-... | CAS号56-86-0 L-谷氨酸 | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号30924-93-7 N-(叔丁氧羰基)-L-谷氨酸... | CAS号1070-19-5 Carbonazidic ac... | CAS号106191-02-0 (S)-5-(((叔丁基二甲基... | CAS号24277-39-2 B°C-L-谷氨酸-1-叔丁酯 | CAS号146453-32-9 B°C-γ-L-二高亮氨酸 | CAS号308242-62-8 瑞米唑仑 | CAS号126587-35-7 (S)-4-叔丁氧羰基氨基-5... | CAS号16364-35-5 环(－Gly-Glu) | CAS号91229-86-6 (S)-5-溴-2-((叔丁氧... | CAS号96014-55-0 (S)-4-叔丁氧羰基氨基-5...

L-谷氨酸置于三甲基氯硅烷体系中,用 1,4-二氧六环,水 作为反应溶剂,化学反应 0.33H,反应生成 N-叔丁氧羰基-L-谷氨酸 5-甲酯
参考文献:肽二硫键模拟物的基于二氨基二酸的固相合成
标题:肽二硫键模拟物的基于二氨基二酸的固相合成
摘要:抗菌肽速激肽i被用作应用标题策略的模型,该策略是为制备具有双二硫化物替代物的肽大环化合物而开发的.发现速激肽i类似物的折叠和活性对二硫化物替代物的结构敏感,因此强调了需要灵活的合成路线来产生具有高结构多样性的二硫键替代物.
DOI:10.1002/anie.201302197

专利信息

专利号:US-9242925-B2
优先权日:2011-08-29
标题:Versatile and stereospecific synthesis of γ,δ-unsaturated amino acids by Wittig reaction
发明人：JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE
权利人:JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE; CENTRE NAT RECH SCIENT; UNIV BOURGOGNE
摘要:The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). n n n n n n n n n n n n Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.

专利号:US-11390590-B2
优先权日:2016-08-16
标 题 :Methods and processes for the preparation of KDM1A inhibitors
发明人：TAPPER AMY E; CELATKA CASSANDRA; ROMERO ARTHUR GLENN; MCCALL JOHN M; CHANCELLOR TONI; CHEN JIAN-XIE; CHEN XUEMEI; ZHAO HE; BIOLATTO BETINA; BROT ELISABETH C A; LI ZHIHUA; LIAO XIAOMING
权利人:IMAGO BIOSCIENCES INC
摘要:Provided in this disclosure are methods for the synthesis of substituted 2-arylcyclopropylamines and 2-heteroarylcyclopropylamines and related compounds. Also provided are methods for reduction of thioesters to aldehydes, and methods for reductive animation of cyclopropylamines.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-4588825-A
优先权日:1983-10-11
标 题 :Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furancarboxylic acid
发明人：BURKHART JOSEPH P; HOLBERT GENE W
权利人:MERRELL DOW PHARMA
摘要:This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C 1-6 lower alkyl esters thereof. These compounds are γ-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.

专利号:US-9840457-B2
优先权日:2013-03-15
标题 :Lysine isotopologues, compositions comprising the same and methods of synthesis
发明人：BRADLEY JOEL CHANDLER; WOOD WILLIAM WAKEFIELD; BARKALLAH SALIM; RYAN WILLIAM JAMES; TITMAS RICHARD CHARLES; SCHWINDEN MARK DONALD; KOZAK JANUSZ KONRAD; ELMASRI MARWAN; TORKELSON STEVEN MICHAEL
权利人:CAMBRIDGE ISOTOPE LABORATORIES INC
摘要:This invention relates to lysine isotopologues of Formulas I and 1-A, as described herein, and processes for synthesizing the same and derivatives and intermediates involved therein. In one aspect, described herein is a chemical compound comprising an isotopically labeled analog, i.e., an isotopologue of a standard or naturally occurring lysine. The lysine isotopologue is synthetically formed to have stable isotopes of elements incorporated at selected positions. As such, the lysine isotopologue has a molecular mass different from the mass of a standard or naturally occurring lysine.

专利号:US-4824974-A
优先权日:1983-10-11
标 题 :Synthesis for the preparation of 4-amino-4,5-dihydro-2-furancarboxylic acid
发明人：BURKHART JOSEPH P; HOLBERT GENE W
权利人:MERRELL DOW PHARMA
摘要:This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C 1-6 lower alkyl esters thereof. These compounds are γ-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.