CAS: 4252-78-2; 2,2',4'-Trichloroacetophenone

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CAS号2234-16-4 2,4-二氯苯乙酮 | CAS号79-04-9 氯乙酰氯 | CAS号541-73-1 间二氯苯 | CAS号1475-13-4 1-(2,4-二氯苯基)乙醇 | CAS号2274-66-0 2,2,2',4'-四氯苯乙酮 | CAS号7446-70-0 氯化铝 | CAS号50-84-0 2,4-二氯苯甲酸 | CAS号46503-52-0 2'-(1H-咪唑-1-基)-... | CAS号134071-10-6 1H-Imidazolium,... | CAS号252950-14-4 2,4-二氯-2-咪唑苯乙酮 | CAS号2234-16-4 2,4-二氯苯乙酮 | CAS号93209-97-3 4-(2,4-二氯苯基)噻唑-2-胺 | CAS号64211-06-9 (Z)-2'-(1H-咪唑-1... | CAS号13692-14-3 Alpha-(氯甲基)-2,4... | CAS号24155-42-8 1-(2,4-二氯苯基)-2-... | CAS号27523-40-6 异康唑

2,2,2',4'-四氯苯乙酮置于对甲苯磺酸体系中,化学反应生成 2,2',4'-三氯苯乙酮
参考文献:Polychlorinated Ketones. Iii. Formation By Acid-Catalyzed Cleavage Of Vinyl Phosphates And Phosphonates
标题:Polychlorinated Ketones. Iii. Formation By Acid-Catalyzed Cleavage Of Vinyl Phosphates And Phosphonates
摘要:
DOI:10.1021/jo01263A072

专利信息

专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-6136984-A
优先权日:1996-04-22
标 题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest is disclosed. The thiophenes are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegier-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:WO-9740034-A1
优先权日:1996-04-22
标题:Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes

专利号:JP-2000508664-A
优先权日:1996-04-22
标题:Solid-phase and combinatorial synthesis of substituted thiophenes and arrays of substituted thiophenes

专利号:CN-108299156-A
优先权日:2018-03-20
标题 :A new method for the synthesis of key chiral intermediates of luliconazole

专利号:EP-1021435-A1
优先权日:1996-04-22
标题:Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes